Abstract Details

Repeat Submandibular Gland Biopsies as a Progression Marker in Parkinson’s Disease
Movement Disorders
S10 - Biomarkers in Movement Disorders (3:41 PM-3:52 PM)
002

We previously reported that SMG biopsy detects LTS in patients with early and advanced Parkinson’s disease (PD). There are no studies of bilateral biopsies or longitudinal biopsies.
Determine  1) feasibility of performing a second submandibular gland (SMG) biopsy in previously biopsied patients, 2) feasibility of doing bilateral SMG biopsies, 3) whether Lewy-type synucleinopathy (LTS) density is the same bilaterally, 4) whether LTS density changes over time.

Seven PD patients (1 female, 6 males; 6 early PD, 1 advanced PD) who previously had positive unilateral SMG biopsies a mean of 4.1 years earlier underwent bilateral transcutaneous needle biopsies of the SMG. Staining with a monoclonal antibody to p-serine 129 alpha-synuclein was performed.
Mean age at time of second biopsy was 76 years and mean time between biopsies was 4.1 years. All subjects had sufficient SMG tissue on at least one side with 12/14 glands biopsies having sufficient tissue for assessment. All 12 glands were positive for LTS with mean percentage of slides positive being the same on right and left side. There was a 4x increase in LTS density on average in the repeat biopsy, with 6 of the patients having an increase and one had a decrease in density. Side effects were similar to previously reported: bruising, swelling, slight bleeding. 

This study, when considered with previous studies, presents firm evidence that transcutaneous needle biopsies of the SMG reproducibly identifies Lewy-type synucleinopathy in living patients with PD. This is the first study to demonstrate 1)bilateral biopsies can be performed safely which improves successful per subject tissue acquisition, 2) similar LTS density bilaterally, and 3) increased LTS density over time. Thus, SMG biopsies are useful as a tissue biomarker for disease diagnosis and potentially for disease progression.
Authors/Disclosures
Charles H. Adler, MD, PhD, FAAN (Mayo Clinic Arizona)
PRESENTER 		Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avion. Dr. Adler has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CND Life Sci. Dr. Adler has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Jazz. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Precon. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine. The institution of Dr. Adler has received research support from NIH. The institution of Dr. Adler has received research support from Michael J. Fox Foundation. The institution of Dr. Adler has received research support from Arizona Biomedical Research Commission. Dr. Adler has received publishing royalties from a publication relating to health care.
No disclosure on file
Geidy Serrano Geidy Serrano has nothing to disclose.
No disclosure on file
Shyamal Mehta, MD, PhD, FAAN (Mayo Clinic, Arizona) Dr. Mehta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Adamas Pharma. Dr. Mehta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Abbott. Dr. Mehta has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CNS Ratings.
No disclosure on file
No disclosure on file
Thomas Beach (Banner Sun Health Research Institute) Thomas Beach has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vivid Genomics. Thomas Beach has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche Diagnostics. The institution of Thomas Beach has received research support from National Institutes of Health. The institution of Thomas Beach has received research support from Michael J Fox Foundation . The institution of Thomas Beach has received research support from State of Arizona.