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Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease

Practice Guideline, November 2021

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This practice guideline update includes conclusions and recommendations that address the efficacy and adverse effects of levodopa, dopamine agonists, and MAO-B inhibitors for treating motor symptoms of early Parkinson disease.

Endorsed by the Parkinson's Foundation.

Reaffirmed on February 8, 2025.

Clinician Tools and Materials

Full-length Version

Download a PDF of the full guideline product, including full details of the methodology and data analysis

Clinician Summary

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Pocket Guideline Clinician Summary

Access a digital interactive summary of the recommendations and other key information from the guideline

Patient Tools and Materials

Patient Summary

Read a summary of the key messages of this guideline product for patients and care partners.

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