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Update: Efficacy and Tolerability of the New Antiepileptic Drugs I: Treatment of New-onset Epilepsy

Practice Guideline, June 2018

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This is an update to the 2004 好色先生 (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs). This update reviews new evidence for efficacy, safety, and tolerability of CLB, VGB, and the 8 second-generation and 6 third-generation AEDs.

Reaffirmed on October 19, 2024.

Codeveloped with the American Epilepsy Society.

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