Abstract Details

Title Childhood Obesity and Risk of Pediatric Multiple Sclerosis and Clinically Isolated Syndrome

Topic MS and Related Diseases

Presentation(s) S10 - (-)

Poster/Presentation
Number 007

Background Obesity is characterized by a low-grade inflammatory state. Over the last 30 years the prevalence of pediatric obesity has tripled.

Objective

Design/Methods Cases were identified through the Kaiser Permanente Southern California (KPSC) Pediatric Acquired Demyelinating Diseases Cohort between 2004 and 2010. For cases, body mass index (BMI) was obtained prior to symptom onset, for the underlying cohort BMI was obtained through the KPSC Children's health study (n =913,097). Weight classes of normal weight, overweight, moderate obesity and extreme obesity were assigned based on BMI specific for age and sex.

Results We identified 75 newly diagnosed pediatric cases of MS or CIS cases the majority of which were girls (n=41, 55%), age 11-18 (n=54, 72%). Obesity was associated with a significantly increased risk of MS/CIS in girls (p=0.005 for trend) but not in boys (p=0.93). The adjusted odds ratio and 95% confidence intervals for CIS/ MS among girls was 1.58 (0.71- 3.50) for overweight compared to normal weight (reference category), 1.78 (0.70 -4.49) for moderately obese, 3.76 (1.54 -9.16) for extremely obese. Moderately and extremely obese cases where more likely to present with transverse myelitis compared with normal/overweight children (p=0.003).

Conclusions Our findings suggest the childhood obesity epidemic is likely to lead to increased morbidity from MS/CIS particularly in adolescent girls.

Authors/Disclosures
Sonu M. Brara, MD (Kaiser Permanente) PRESENTER	No disclosure on file
Annette M. Langer-Gould, MD, PhD (Kaiser Permanente Southern California)	An immediate family member of Dr. Langer-Gould has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Annals of American Thoracic Society. The institution of Dr. Langer-Gould has received research support from PCORI. The institution of an immediate family member of Dr. Langer-Gould has received research support from PCORI, ARQ, NIH. Dr. Langer-Gould has a non-compensated relationship as a Voting Member with ICER CTAF Panel that is relevant to AAN interests or activities.
Brandon E. Beaber, MD (Kaiser Permanente)	No disclosure on file
	No disclosure on file
John M. Stern, MD, FAAN	Dr. Stern has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for UCB Pharma. Dr. Stern has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for SK Life Science. Dr. Stern has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Neurelis. Dr. Stern has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Ceribell. Dr. Stern has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Jazz Pharma. Dr. Stern has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for LivaNova. Dr. Stern has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Neurelis. Dr. Stern has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for LivaNova. Dr. Stern has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sunovion. Dr. Stern has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Jazz. Dr. Stern has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for SK Life Sciences. Dr. Stern has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for MedLink Neurology. Dr. Stern has stock in DEARhealth. Dr. Stern has stock in Ceribell. Dr. Stern has received publishing royalties from a publication relating to health care. Dr. Stern has received publishing royalties from a publication relating to health care. Dr. Stern has received publishing royalties from a publication relating to health care. Dr. Stern has received publishing royalties from a publication relating to health care.

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