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Abstract Details

Wearable Sensors for the Quantification of Motor Symptom in Parkinson Disease and Huntington Disease
Movement Disorders
N5 - Neuroscience in the Clinic: Wearable Technology (4:45 PM-5:00 PM)
002

Current measures for quantifying motor symptoms in Parkinson disease (PD) and Huntington disease (HD) are subjective and categorical.  Objective, and continuous measures for symptoms such as tremor, gait disturbance, and Huntington’s chorea are needed.

To develop novel measures of quantifying the motor symptoms of Parkinson disease and Huntington disease.  

We conducted a 12 month observational study of 56 individuals: 16 with PD, 15 with HD, 5 with prodromal HD, and 20 healthy controls. Participants wore wearable sensors for an in-clinic evaluation followed by a two day at-home observation period at baseline and months 6, 9 and 12. Through the application of signal process theory, we have developed novel algorithms for quantifying parkinsonian tremor as well as Huntington’s chorea. Our tremor algorithm is capable of producing a continuous, objective, frequent score, which reflects the strength of tremor in the arms. Our chorea score quantifies the amount of non-deliberate involuntary jerky movement in the chest over a given period of time.

 

Based on analysis of the baseline visit, the tremor score was able to differentiate individuals with PD from controls as well as detect response to levodopa. Using the chorea algorithm, we were able to clearly distinguish individuals with HD from controls as well as individuals with prodromal HD from individuals with manifest HD.  Individuals with manifest HD were segregated based on clinician-rated Unified Huntington Disease Rating Scale (UHDRS) scores. Chorea analysis on the segregated data showed a positive correlation between the algorithmic score and the UHDRS score.

While further analysis is required to determine the reliability of these new measures, current results suggest that wearable sensors offer an effective means for quantifying motor symptoms and identifying patterns that elude current measures in PD and HD. These measures have the potential to enhance clinical trials, speed therapeutic development, and improve patient-centered care.

Authors/Disclosures
Jamie L. Adams, MD (University of Rochester Medical Center)
PRESENTER
Dr. Adams has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVie. Dr. Adams has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Michael J. Fox Foundation. Dr. Adams has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for BioSensics. The institution of Dr. Adams has received research support from NIH/NINDS. The institution of Dr. Adams has received research support from Biogen. The institution of Dr. Adams has received research support from The Michael J. Fox Foundation. The institution of Dr. Adams has received research support from Critical Path Institute. Dr. Adams has received personal compensation in the range of $500-$4,999 for serving as a KINECT-HD Steering Committee Member with Huntington Study Group. Dr. Adams has received personal compensation in the range of $500-$4,999 for serving as a ORCHESTRA-PD Steering Committee Member with Parkinson Study Group.
No disclosure on file
No disclosure on file
E. Ray Dorsey, MD, MBA (University of Rochester) Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Seelos Therapeutics. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eden McCallum, LLP. Dr. Dorsey has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genentech/Roche. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biohaven Pharmaceuticals. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for WebMD. Dr. Dorsey has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for BioSensics. Dr. Dorsey has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Mediflix. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cerevance. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Kairos Cinema, LLC. Dr. Dorsey has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Mitsubishi Tanabe Pharma America Inc.. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for HanAll. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Dorsey has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Advarra. Dr. Dorsey has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medrhythms. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ANA. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for HMP 好色先生, LLP. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ADIVO Associates France. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for University of Toronto. Dr. Dorsey has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philadelphia Neurological Society. Dr. Dorsey has stock in Included Health. Dr. Dorsey has stock in Mediflix. Dr. Dorsey has stock in SemCap. Dr. Dorsey has stock in Synapticure. The institution of Dr. Dorsey has received research support from NIH/NINDS. The institution of Dr. Dorsey has received research support from Burroughs Wellcome . The institution of Dr. Dorsey has received research support from Michael J. Fox Foundation - Fox Insight. The institution of Dr. Dorsey has received research support from Michael J. Fox Foundation - Emerald. The institution of Dr. Dorsey has received research support from B. Thomas Golisano Foundation. The institution of Dr. Dorsey has received research support from Emerald Innovations, Inc.. The institution of Dr. Dorsey has received research support from Photopharmics Inc.. The institution of Dr. Dorsey has received research support from Averitas Pharma Inc.. The institution of Dr. Dorsey has received research support from DOD/Army Medical Research Acquisition Activity. The institution of Dr. Dorsey has received research support from NIH/NINDS.
No disclosure on file