Abstract Details

Title Long-term Exposure to Ambient Air Pollution and Trajectories of Cognitive Decline among Older Adults in Northern Manhattan

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) S34 - Aging and Dementia: Risk Factors, Biomarkers, and Neuropathology (1:00 PM-1:11 PM)

Poster/Presentation
Number 001

Background Age-related cognitive decline is a growing public health issue as increases in life expectancy are expected to substantially raise the prevalence of cognitive impairment and dementia. Emerging evidence suggests that ambient air pollution from traffic and other sources may be an important risk factor for cognitive decline in addition to its association with other cardiovascular and neurological outcomes.

Objective To investigate the association between long-term exposure to ambient air pollution and cognitive decline in older adults residing in Northern Manhattan.

Design/Methods The Northern Manhattan Stroke Study and the Washington Heights Inwood Community Aging Project were harmonized into a single prospective analytical cohort. At baseline, participants received in-depth neuropsychological testing and examinations to assess health status and risk factors. Follow-up neuropsychological testing is ongoing. We used latent growth curve models to evaluate the association between markers of ambient air pollution at baseline (fine [PM_2.5] and course [PM₁₀] particulate matter, nitrogen dioxide [NO₂], and distance to roadway) and measures of global and domain-specific cognition at baseline and across trajectories, adjusting for sociodemographic factors and temporal trends.

Results Among 6,206 participants we observed a cross-sectional association between ambient air pollution and global cognitive scores at baseline. In fully adjusted models, an interquartile range increase in PM_2.5was associated with a 0.09 unit lower global cognitive score at baseline (95% CI -0.15, -0.03), equivalent to approximately 4 months of aging. Results for PM₁₀ and NO₂ and from individual functional cognitive domains were similar. We found little evidence of an association between air pollution and change in cognitive function over time.

Conclusions

This study found that individuals living in areas with higher levels of ambient air pollutants have lower cognition scores at baseline, but little evidence that these pollutants were associated with changes in cognitive function over time.

Authors/Disclosures
Erin R. Kulick, PhD PRESENTER	No disclosure on file
	No disclosure on file
Amelia K. Boehme, PhD (Columbia University)	Dr. Boehme has nothing to disclose.
Nicole Schupf, PhD, DrPH	No disclosure on file
Richard P. Mayeux, MD, MSc, FAAN (The Neurological Institute, Columbia University Medical Center)	Dr. Mayeux has nothing to disclose.
Ralph L. Sacco, MD, MS, FAHA	Dr. Sacco has received personal compensation in the range of $100,000-$499,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association. The institution of Dr. Sacco has received research support from NIH, NINDS, NCATS, NIMHD. The institution of Dr. Sacco has received research support from FL Department of Health. Dr. Sacco has received research support from University of Washington, Seattle. Dr. Sacco has received publishing royalties from a publication relating to health care.
Jennifer J. Manly, PhD (Columbia University)	The institution of Dr. Manly has received research support from NIH. Dr. Manly has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant with University of Mississippi.
Mitchell S. Elkind, MD, MS, FAAN	Dr. Elkind has received personal compensation for serving as an employee of American Heart Association. Dr. Elkind has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Atria Academy.

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