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Abstract Details

Long-term Exposure to Ambient Air Pollution and Trajectories of Cognitive Decline among Older Adults in Northern Manhattan
Aging, Dementia, and Behavioral Neurology
S34 - Aging and Dementia: Risk Factors, Biomarkers, and Neuropathology (1:00 PM-1:11 PM)
001
Age-related cognitive decline is a growing public health issue as increases in life expectancy are expected to substantially raise the prevalence of cognitive impairment and dementia. Emerging evidence suggests that ambient air pollution from traffic and other sources may be an important risk factor for cognitive decline in addition to its association with other cardiovascular and neurological outcomes.
To investigate the association between long-term exposure to ambient air pollution and cognitive decline in older adults residing in Northern Manhattan.
The Northern Manhattan Stroke Study and the Washington Heights Inwood Community Aging Project were harmonized into a single prospective analytical cohort.  At baseline, participants received in-depth neuropsychological testing and examinations to assess health status and risk factors. Follow-up neuropsychological testing is ongoing. We used latent growth curve models to evaluate the association between markers of ambient air pollution at baseline (fine [PM2.5] and course [PM10] particulate matter, nitrogen dioxide [NO2], and distance to roadway) and measures of global and domain-specific cognition at baseline and across trajectories, adjusting for sociodemographic factors and temporal trends.
Among 6,206 participants we observed a cross-sectional association between ambient air pollution and global cognitive scores at baseline. In fully adjusted models, an interquartile range increase in PM2.5 was associated with a 0.09 unit lower global cognitive score at baseline (95% CI -0.15, -0.03), equivalent to approximately 4 months of aging. Results for PM10 and NO2 and from individual functional cognitive domains were similar. We found little evidence of an association between air pollution and change in cognitive function over time.

This study found that individuals living in areas with higher levels of ambient air pollutants have lower cognition scores at baseline, but little evidence that these pollutants were associated with changes in cognitive function over time.

Authors/Disclosures
Erin R. Kulick, PhD
PRESENTER
No disclosure on file
No disclosure on file
Amelia K. Boehme, PhD (Columbia University) Dr. Boehme has nothing to disclose.
Nicole Schupf, PhD, DrPH No disclosure on file
Richard P. Mayeux, MD, MSc, FAAN (The Neurological Institute, Columbia University Medical Center) Dr. Mayeux has nothing to disclose.
Ralph L. Sacco, MD, MS, FAHA Dr. Sacco has received personal compensation in the range of $100,000-$499,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association. The institution of Dr. Sacco has received research support from NIH, NINDS, NCATS, NIMHD. The institution of Dr. Sacco has received research support from FL Department of Health. Dr. Sacco has received research support from University of Washington, Seattle. Dr. Sacco has received publishing royalties from a publication relating to health care.
Jennifer J. Manly, PhD (Columbia University) The institution of Dr. Manly has received research support from NIH. Dr. Manly has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant with University of Mississippi.
Mitchell S. Elkind, MD, MS, FAAN Dr. Elkind has received personal compensation for serving as an employee of American Heart Association. Dr. Elkind has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Atria Academy.