Abstract Details

Title Factors Related to Higher Neurobiological Capital Across the Lifespan: Mayo Clinic Study of Aging

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) S34 - Aging and Dementia: Risk Factors, Biomarkers, and Neuropathology (1:11 PM-1:22 PM)

Poster/Presentation
Number 002

Background Three anatomically distinct regions play an important role in cognitive aging: Entorhinal cortex is susceptible to aging/pathology, parietal lobe is an integrative functional hub, and frontal lobe may reflect early cerebrovascular disease. Here, we used imaging measures in these regions to capture associations with protective and risk factors for each subject – Entorhinal cortex (ERC) thickness, superior parietal lobe (SUP) thickness, and DTI-based genu corpus-callosum fractional anisotropy (GCC).

Objective Our goal was to examine risk factors and cognitive outcomes for imaging measures related to cognitive aging across the lifespan.

Design/Methods We identified 796 (30-49 years, n=127; 50-64 years, n=558; ≥65 years, n=111) population-based individuals (30.8-93.0 years, 48.2% female) with imaging from the Mayo Clinic Study of Aging. We computed each of the imaging measures and created a composite score from a percentile-based ranking system for individual measures. We investigated protective and risk factors and cognitive outcomes associated with individual imaging measures and the imaging composite score using t-test and chi-square. Significant relationships at p<0.05 are discussed.

Results In 30-49 year olds, higher GCC was related to greater total brain volume and higher ERC thickness was related to better memory performance. In 50-64 year olds, higher imaging measures were related to lower current metabolic/vascular risk (composite and ERC thickness), greater total brain volume (composite and GCC), higher global cognition (composite and SUP thickness), lower history of smoking/alcohol problems (composite and SUP thickness), and higher prevalence of marriage (ERC and SUP thickness). Elderly (≥65 years old) with high imaging measures had higher prevalence of marriage (all measures) and lower history of alcohol problems (composite) compared to young adults with high imaging measures.

Conclusions Each of the imaging measures captures a unique aspect of cognitive aging. Imaging biomarkers associated with distinct risk and protective factors will be useful for building a richer conceptual model of cognitive aging.

Authors/Disclosures
Bryan J. Neth, MD, PhD (Mayo Clinic) PRESENTER	Dr. Neth has nothing to disclose.
Jonathan Graff-Radford, MD, FAAN	Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NINDS/NIH. The institution of Dr. Graff-Radford has received research support from NIH. The institution of Dr. Graff-Radford has received research support from Eisai. The institution of Dr. Graff-Radford has received research support from Cognition therapeutics.
Scott Przybelski	Scott Przybelski has nothing to disclose.
Christopher Schwarz	The institution of Christopher Schwarz has received research support from NIH.
Robert Reid (BioDirection)	No disclosure on file
Michelle M. Mielke, PhD (Wake Forest University School of Medicine)	Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LabCorp. Dr. Mielke has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Siemens Healthineers. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sunbird Bio. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Mielke has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novo Nordisk.
Ronald C. Petersen, MD, PhD, FAAN (Mayo Clinic)	Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly and Co.. Dr. Petersen has received personal compensation in the range of $0-$499 for serving as a Consultant for Eisai, Inc.. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novo Nordisk. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has a non-compensated relationship as a Board of Directors with American Brain Foundation that is relevant to AAN interests or activities.
Clifford R. Jack, Jr., MD (Mayo Clinic)	The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic.
David S. Knopman, MD, FAAN (Mayo Clinic)	Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.
Prashanthi Vemuri, PhD (Mayo Clinic)	The institution of Dr. Vemuri has received research support from NIH.

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