Abstract Details

Title Recurrent Transient Global Amnesia

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) S13 - Behavioral and Cognitive Neurology: Behavioral Neurology, Aging, and Dementia (1:11 PM-1:22 PM)

Poster/Presentation
Number 002

Background TGA is usually an isolated event; though recurrence rates vary considerably among studies. Compared to single cases, recurrent episodes may reflect increased susceptibility to physiological, environmental, or genetic factors.

Objective To determine risk factors for recurrence of transient global amnesia (TGA).

Design/Methods Cross sectional retrospective study of 1044 cases of TGA presenting to Mayo Clinic in Rochester, Minnesota between 1992 and 2017. Comparison of single versus recurrent cases, focusing on demographics, precipitating factors, comorbid medical conditions, and family history.

Results There were 901 single and 143 recurrent cases. The two groups were similar in age at the time of analysis, sex, identifiable triggers, and duration of anterograde amnesia. Average interval between recurrent episodes was 3.9 +/- 4.7 years. The number of recurrences ranged from one to nine, with greater than 95% of individuals having three or fewer recurrences in their lifetime. Average age at first onset of TGA was 65.2 +/- 10 years for single cases versus 58.8 +/- 10.3 years for recurrent cases (p < .0001). There was a personal history of migraine in 20% of single and 36.4% of recurrent cases (p < .0001). There was either a personal or family history of migraine in 31.3% of single and 50.4% of recurrent cases (p < .0001). A family history of TGA was identified in 12 single and 4 recurrent cases.

Conclusions Our study suggests that recurrent TGA is associated with earlier age of onset and higher frequency of both personal and family history of migraine compared to isolated cases.

Authors/Disclosures
Kenneth A. Morris, MD, PhD (University of Colorado Health) PRESENTER	No disclosure on file
Alejandro A. Rabinstein, MD, FAAN (Mayo Clinic)	Dr. Rabinstein has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Boston Scientific. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Shionogi . Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Chiesi. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ceribell. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurocritical care/NCS-Springer. Dr. Rabinstein has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wolters/UptoDate. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for EBSCO/DynaMed. Dr. Rabinstein has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for AHA. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care.
Nathan P. Young, DO (Mayo Clinic)	Dr. Young has nothing to disclose.

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