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Abstract Details

Hoarding and Obsessive-Compulsive Behaviours in Frontotemporal Dementia: Clinical and Neuroanatomical Associations
Aging, Dementia, and Behavioral Neurology
S13 - Behavioral and Cognitive Neurology: Behavioral Neurology, Aging, and Dementia (2:06 PM-2:17 PM)
007

Hoarding and obsessive-compulsive behaviours are well documented symptoms in FTD. While contemporary models consider hoarding and obsessive-compulsive disorder distinct, the behaviours have not been separately examined in patients with FTD. The neuroanatomical correlates of hoarding in patients with FTD have not been determined, while findings for OCB have been inconsistent.

To elucidate the neuroanatomical basis of hoarding and obsessive-compulsive behaviours (OCB) in frontotemporal dementia (FTD). 

Patients with FTD who were evaluated between April 2004 and May 2018 at our centre were included. The presence of hoarding or OCB was ascertained through review of all available clinical evaluations and symptom questionnaires. Cortical thickness and subcortical volumetric analyses were completed on available T1 high resolution anatomic scans using FreeSurfer.

We identified 87 patients who met inclusion criteria. 49 had scans available for quantitative MRI volumetric analysis. New or increased hoarding behaviours were present in 28% of patients, while 49% of individuals had new or increased OCB. Hoarding behaviours were more commonly associated with the semantic variant subtype of FTD, while non-fluent primary progressive aphasia was less frequently associated with OCB or hoarding.  Hoarding behaviours were associated with decreased left inferior temporal, superior temporal and temporal pole cortical thickness. The presence of OCB was predicted by greater cortical thickness in the right superior, middle, inferior temporal cortices.

The association of the semantic variant with hoarding, together with the observed associations between left temporal atrophy and hoarding indicate that degeneration of the left temporal lobe has a critical role in the emergence of hoarding in FTD. Greater right temporal volumes predicted the presence of OCB. As in current models of Hoarding disorder and Obsessive-Compulsive disorder, our results suggest that in patients with FTD, hoarding and OCB are clinically and anatomically distinct phenomenon.
Authors/Disclosures
Eric Mitchell
PRESENTER
No disclosure on file
No disclosure on file
No disclosure on file
Elizabeth Finger, MD, FAAN Dr. Finger has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vigil Neuro. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Denali Therapeutics. The institution of Dr. Finger has received research support from CIHR. The institution of Dr. Finger has received research support from Physician Servcices Incorporated. The institution of Dr. Finger has received research support from Weston Foundation. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving as a Annual Meeting Course Director with 好色先生.