好色先生

好色先生

Explore the latest content from across our publications

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

The Matrix Gla Protein (MGP) rs1800801 is Associated With First Year Recurrence of Ischemic Stroke in Caucasians
Cerebrovascular Disease and Interventional Neurology
S22 - Stroke Genetics, Cellular Responses, and Animal Models (4:25 PM-4:36 PM)
006

Recurrent ischemic stroke is associated with increased morbidity and mortality. The matrix gamma-carboxyglutamatic acid Gla protein (MGP) is an extracellular matrix protein involved in the inhibition of vascular calcification. The MGP rs1800801 single nucleotide polymorphism (SNP) specifically is associated with recurrent ischemic stroke. Here, we explored the relationship between this SNP and recurrence of ischemic stroke within one year in a Northeastern Pennsylvania cohort. 

To identify associations between the matrix gamma-carboxyglutamic acid Gla protein rs1800801 single nucleotide polymorphism and risk of recurrent ischemic stroke. 

We retrospectively reviewed a cohort of Caucasian acute ischemic stroke patients admitted between 10/2009 and 12/2016 who enrolled in a system-wide exome sequencing program at a large healthcare system in Northeastern Pennsylvania. Patients admitted in 2016 were assessed for recurrent strokes until 12/2017. We then compared the rs1800801 SNP in patients with recurrent stroke within one year against those without recurrent stroke. 

1,068 patients had ischemic stroke and exome sequencing completed, deeming them eligible for inclusion. 79 (7.4%) patients had recurrent ischemic events.  Multivariable analysis suggested hypercoagulability (OR = 3.563, 95% CI 1.504 – 8.443, p = 0.004), prior stroke (OR 9.694, 95% CI 5.793 – 16.224, p ≤ 0.001), and the AA genotype of SNP rs1800801 (OR = 2.408, 95% CI 1.079 – 4.389, p = 0.004) were independently associated with recurrent stroke within one year.  Family history of stroke shows a positive trend towards recurrent stroke (OR = 1.698, 95% CI 0.988 – 2.916, p = 0.055). 

The AA genotype of the rs1800801 SNP is independently associated with recurrent ischemic stroke within one year among Northeastern Pennsylvania Caucasians. Although risk of recurrence is still undetermined in subgroups of Caucasians, these findings may contribute to the development of preventative measures for patients with high risk genetic profile for recurrent ischemic stroke. 

Authors/Disclosures
Saran Kunaprayoon
PRESENTER
No disclosure on file
No disclosure on file
Nelson Sofoluke (The Commonwealth Medical College) No disclosure on file
Matthew D. Adams No disclosure on file
Ramin Zand, MD (Pennsylvania State University) Dr. Zand has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Spangenberg Shibley & Liber LLP. The institution of Dr. Zand has received research support from Genentech. The institution of Dr. Zand has received research support from Geisinger Health Plan. The institution of Dr. Zand has received research support from Geisinger Health Plan. The institution of Dr. Zand has received research support from Bucknell.
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Natalia S. Rost, MD, MPH, FAHA, FAAN (Massachusetts General Hospital) Dr. Rost has received personal compensation in the range of $50,000-$99,999 for serving as an officer or member of the Board of Directors for 好色先生. Dr. Rost has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Stroke - AHA/ASA Journal. The institution of Dr. Rost has received research support from NIH. Dr. Rost has received publishing royalties from a publication relating to health care.
No disclosure on file
No disclosure on file