Abstract Details

Title Association of Carotid Arterial Atherosclerosis, Dilation, and Stiffness with Cerebral Small Vessel Disease

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S35 - Stroke Prevention Strategies (2:17 PM-2:28 PM)

Poster/Presentation
Number 008

Objective We aim to investigate the associations of carotid atherosclerosis, dilation, and stiffness with imaging markers of cerebral small vessel disease (CSVD) in a community-based sample, and further to explore the spatial distribution of these lesions.

Background Cumulative evidence suggest that carotid arterial properties are related to CSVD.

Design/Methods The study comprised 1051 participants (57.5 ± 9.2 years) who underwent brain magnetic resonance imaging and ultrasound examination of carotid plaque. Intima-media thickness (IMT), diastolic diameter, pulse wave velocity (PWV), and stiffness index β of common carotid arteries (CCA) were measured using radiofrequency-based tracking system. Lacunes, cerebral microbleeds (CMB), and dilated perivascular spaces (PVS) were visually rated, and white matter hyperintensities (WMH) were automatically segmented. The associations between carotid properties and CSVD were evaluated with multiple logistic and linear regression models.

Results Increasing CCA-IMT (per 1mm) was independently associated with larger WMH volume (β±SE, 0.001±0.001; P=0.03) and deep or infratentorial CMB (OR, 1.01; 95% CI, 1.00–1.01; P=0.01). Carotid plaque was significantly associated with presence of lacunes (OR, 2.78; 95% CI, 1.78–4.33; P<0.001) and larger WMH volume (β±SE, 0.32±0.10; P=0.002). One-millimeter increment in CCA diameter was associated with doubling risk of prevalent lacunes and deep or infratentorial CMB (OR, 1.82, 95% CI, 1.22–2.72 for lacunes; OR, 2.19, 95% CI, 1.11–4.34 for deep or infratentorial CMB), 60% excess risk of prevalent dilated PVS in basal ganglia (OR, 1.59; 95% CI, 1.20–2.11; P=0.001), and 0.37 ml excess WMH (β±SE, 0.37±0.10; P<0.001). Associations of CCA dilation and CSVD was independent of carotid IMT and plaque. Carotid stiffness was not found to be associated with CSVD.

Conclusions Carotid atherosclerosis and dilation are associated with imaging markers of CSVD. Most of these lesions are located in the basal ganglia and deep white matter. Noninvasive carotid assessment seems to be a rational approach to risk stratification of CSVD.

Authors/Disclosures
Fei-Fei Zhai PRESENTER	Fei-Fei Zhai has nothing to disclose.
	No disclosure on file
Fei Han	Fei Han has nothing to disclose.
Lixin Zhou	Lixin Zhou has nothing to disclose.
Jun Ni	Jun Ni has nothing to disclose.
Ming Yao	Ming Yao has nothing to disclose.
Shu-Yang Zhang	No disclosure on file
Zheng-Yu Jin	No disclosure on file
Liying Cui, PhD (Peking Union Medical College Hospital)	No disclosure on file
	No disclosure on file
Yi-Cheng Zhu, MD, PhD (Peking Union Medical College Hospital)	Dr. Zhu has nothing to disclose.

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