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Abstract Details

Sociodemographic Characteristics and Mortality Associated with Incident Epilepsy Among Medicare Beneficiaries
Epilepsy/Clinical Neurophysiology (EEG)
S48 - Epilepsy/Clinical Neurophysiology (EEG) III (1:55 PM-2:06 PM)
006
Older adults are at risk of developing epilepsy due to a high burden vascular, structural, and metabolic disorders. However, recent estimates of epilepsy incidence and associated mortality are lacking.

To determine the incidence of epilepsy among Medicare beneficiaries, and the 5-year mortality associated with incident epilepsy diagnosis.

We performed a retrospective cohort study of Medicare beneficiaries with complete data for the year 2009. Incident epilepsy cases were identified in 2009 using validated ICD-9 and procedure code-based algorithms, and death was assessed through 2014. The incidence of epilepsy was examined by demographic characteristics. Cox regression models were built to examine mortality associated with incident epilepsy, and to determine whether mortality differed by demographic characteristics.

Among the 113, 590 Medicare beneficiaries who were diagnosed with epilepsy in 2009, 56.9% were male, 79.5% were identified as white, and mean age was 76.9 years (SD 8.3). The five-year mortality rate for incident epilepsy was 59.2% (n=67,262).  In adjusted models, blacks had a higher mortality (AHR 1.34, 1.01-1.65).  Female sex was associated with lower mortality (AHR 0.82, 0.81, 0.84).

New onset epilepsy is associated with high 5-year mortality among Medicare beneficiaries. In addition, there are significantly different mortality rates in certain subpopulations—blacks have higher mortality and females have lower mortality. Future studies will be needed to better understand race and sex differences in mortality after a new epilepsy diagnosis.

Authors/Disclosures
Emily K. Acton (University of Pennsylvania)
PRESENTER
No disclosure on file
Leah Blank, MD (Icahn School of Medicine at Mount Sinai) The institution of an immediate family member of Dr. Blank has received personal compensation in the range of $0-$499 for serving as a Consultant for Bristol Myers Squibb (Legal). The institution of Dr. Blank has received research support from American Epilepsy Foundation/Epilepsy Foundation/NORSE Foundation. The institution of Dr. Blank has received research support from NIA (Mount Sinai OAIC).
Kathryn A. Davis, MD (University of Pennsylvania) Dr. Davis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GW Pharmaceuticals/Jazz Pharmaceuticals. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Spark Therapeutics. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UNEEG. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Epilepsia Open. Dr. Davis has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Pfizer. The institution of Dr. Davis has received research support from Eisai. The institution of Dr. Davis has received research support from Liminal. Dr. Davis has received publishing royalties from a publication relating to health care.
Allison Wright Willis, MD (University of Pennsylvania) Dr. Wright Willis has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Pharmacoepidemiology and Drug Safety. Dr. Wright Willis has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Wright Willis has received research support from NIH. The institution of Dr. Wright Willis has received research support from NIA. The institution of Dr. Wright Willis has received research support from Biogen. The institution of Dr. Wright Willis has received research support from Parkinson Foundation. The institution of Dr. Wright Willis has received research support from Arcadia.