Abstract Details

Title Incidence and predictors of in hospital mortality associated with status epilepticus: an estimate using the Nationwide Inpatient Sample (NIS) database (2011-2014)

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) S48 - Epilepsy/Clinical Neurophysiology (EEG) III (2:17 PM-2:28 PM)

Poster/Presentation
Number 008

Background Status epilepticus (SE) is a life-threatening neurological emergency associated with higher mortality.

Objective We utilized the NIS database to study trends and predictors of mortality associated with a primary diagnosis of status epilepticus.

Design/Methods

Patients aged ≥ 18 years with a primary diagnosis of Status epilepticus were identified from the Nationwide Inpatient Sample (NIS) from 2011 to 2014 using ICD-9 CM diagnosis code 345.2 and 345.3. Differences between categorical variables were tested using the chi-square test and continuous variables using the Student t-test. P values for trends were generated by Cochrane-Armitage test for categorical variables and simple linear regression for continuous variables.

Results We identified 76,370 patients with primary diagnosis of status epilepticus (Mean age 52 ± 19 years, 52.3% male, 56.4% white) during our study period, of which 346 (0.45%) had Petit mal and 76024 had Grand mal seizures. Multivariate analysis for predictors of mortality showed increasing age per year (OR:1.04, 95% CI:1.03-1.05, p<0.001), Higher comorbidity index (OR:1.19, 95% CI:1.14-1.24, p<0.001), comorbidities such as diabetes milletus (OR:1.51, 95% CI:1.21-1.88, p<0.001), chronic kidney disease (OR:2.24, 95% CI:1.73-2.89, p<0.001), chronic liver disease (OR:1.98, 95% CI:1.34-2.91, p=0.001), fluid and electrolyte disturbance (OR:2.03, 95% CI:1.67-2.47, p<0.001), admission in a teaching hospital (OR:1.85, 95% CI:1.49-2.28, p<0.001) were predictors of increased mortality. African American (OR:0.66, 95% CI:0.51-0.85, p=0.001) and Hispanics (OR:0.60, 95% CI:0.41-0.89, p=0.010) patient population as compared to Caucasian were associated with decreased mortality.

Conclusions

Comorbidities such as diabetes, chronic kidney disease, chronic liver disease, higher comorbidity index and increasing age were significant predictors of mortality in patients hospitalized with the primary diagnosis of status epilepticus. Proactively addressing these comorbidities during hospitalization may help reduce mortality in this population.

Authors/Disclosures
Sheyar Amin, MD (University of South Florida) PRESENTER	Dr. Amin has nothing to disclose.
Chirag N. Savani, MD (Tampa General Hospital)	No disclosure on file
Colby A. Richardson, MD (TeleSpecialists, LLC)	Dr. Richardson has nothing to disclose.
	No disclosure on file
Stephanie E. MacIver, MD (University of South Florida Department of Neurology)	No disclosure on file
	No disclosure on file
Selim R. Benbadis, MD, FAAN (University of South Florida)	Dr. Benbadis has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Stratus. Dr. Benbadis has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for SK Lifesciences. Dr. Benbadis has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for Jazz. Dr. Benbadis has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Catalyst. Dr. Benbadis has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for Neurelis. Dr. Benbadis has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sunovion. Dr. Benbadis has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Livanova. Dr. Benbadis has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for UCB.

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