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Abstract Details

Familial Transmission of Migraine and Mood Disorders- Evidence from a High Risk Study
Headache
S59 - Migraine: Impact, Treatment Patterns and Resource Utilization (1:44 PM-1:55 PM)
005
Despite identification of several genetic markers associated with migraine a thorough understanding of its risk and etiologic factors is still challenged by its heterogeneity

Our chief objectives were to describe: 1)The familial transmission of migraine by sex and subtype; and

2) The familial co-aggregation of migraine with mood and anxiety disorders.


Sample - participants enrolled in the National Institute of Mental Health's Family Study of Affective Spectrum Disorders, in the greater Washington DC metropolitan area examining the full range of mood disorders and migraine.  Familial aggregation analysis included 353 offspring from 200 families. Migraine diagnoses were derived from ICHD-II based and previously validated headache questionnaires. The association between proband and relative migraine was evaluated using mixed effects logistic regression.


Migraine in parent probands was significantly associated with migraine among offspring (OR = 3.1; 95%CI: 1.7-5.5) and was more prevalent in female offspring (OR = 2.0; CI: 1.2-3.3). There was no significant influence of parental gender on risk of migraine among offspring. Concomitant symptoms of anxiety were prominent among the offspring with migraine. Anxiety and migraine were independently transmitted from parent to offspring.


 The lack of effect of sex of the affected parent suggests that genetic factors cannot explain the female preponderance of migraine. Increased risk of migraine in females is likely to result from increased exposure to non-familial endogenous or exogenous risk factors for migraine that lower the threshold for expression of migraine in women. While anxiety and migraine are strongly familial, their association with migraine does not appear to be highly transmissible.

 


Authors/Disclosures

PRESENTER
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file