Migraine is an extraordinarily prevalent neurological disease affecting 39 million individuals in the U.S., and 1 billion worldwide. Data regarding readmission rates within 30 days of discharge from index hospitalization for Status Migrainosus remains poorly reported.

To identify the incidence and predictors of 30-day readmission and prolonged length of stay in patients with Status Migrainosus.

The Nationwide Readmission Database from 2010–2014 was queried using the International Classification of Diseases-Ninth Edition codes to identify all patients 18 years of age and older who were readmitted within 30 days after a hospital discharge for Status Migrainosus. The incidence and predictors of 30-day readmission and prolonged length of stay (LOS) were analyzed.

Among the 30,643 patients who survived through discharge for Status Migrainosus, 3,149 (10.3%) were readmitted within 30 days. Higher burden of comorbidity (OR:1.43, 95% CI:1.20-1.72, p<0.001) and comorbid conditions like Mood Disorders (OR:1.23 95% CI:1.11-1.36, p<0.001), Hypothyroidism (OR:1.33, 95% CI:1.16-1.53, p<0.001), Heart Failure (OR:1.55, 95% CI:1.04-2.32, p=0.032), and prolonged LOS (OR:1.07, 95% CI:1.06-1.09, p<0.001) were predictive of 30-day readmission. Females (OR: 1.39, 95% CI: 1.14-1.68, p<0.001), and comorbidities like Mood Disorder (OR:1.27, 95% CI:1.12-1.45, p<0.001), Anxiety Disorder (OR:1.52, 95% CI:1.32-1.75, p<0.001), Opioid Abuse (OR:2.23, 95% CI:1.49-3.33, p<0.001), Hypertension (OR:1.40, 95% CI:1.22-1.61, p<0.001), Diabetes Mellitus (OR:1.27, 95% CI:1.05-1.55, p=0.016), Chronic Renal Failure (OR:1.71, 95% CI:1.13-2.59, p=0.011), and Chronic Liver Disease (OR:1.97, 95% CI:1.29-3.00, p=0.002), were associated with prolonged LOS. Alternatively, private insurance (OR:0.81, 95% CI:0.70-0.92, p=0.002) and elective admission (OR:0.80, 95% CI:0.66-0.97, p=0.027) were associated with decreased LOS.

In this large, national-representative study, approximately 1 in 10 patients were readmitted within 30 days of discharge after admission for Status Migrainosus. We identified factors associated with increased readmission and prolonged length of stay. This data can be utilized to identify potentially preventable readmissions.