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Abstract Details

Electroencephalogram-Based Brain Age in People Living With HIV
Infectious Disease
S29 - NeuroHIV: Pathophysiology and Clinical Phenotypes (4:58 PM-5:09 PM)
009

Age-related co-morbidities affect HIV+ adults at younger ages, raising concern for accentuated brain aging. Our lab previously showed that an EEG-based model of brain age reliably predicts chronological age in healthy adults. The differences between EEG-brain age and chronological age, the brain age index (BAI), independently predicts mortality. BAI is also increased by cardiovascular comorbidities. We hypothesized that HIV+ adults have an older brain age and thus higher BAI compared to HIV-negative (HIV-) controls.

To estimate the effect of HIV-1 infection  (HIV+) during antiretroviral therapy (ART) on brain age using a novel sleep-EEG-based biomarker.

HIV+ adults with sleep EEGs (n=60) were identified from the Partners HealthCare Systems Research Patient Data Registry and group differences in BAI were compared to healthy HIV- controls (n=600) lacking major neurological and psychological disease. To estimate the independent effect of HIV infection on brain age, the HIV+ cohort was matched by age, gender, smoking, hypertension, diabetes, and neuropsychiatric illness using a larger sleep dataset of HIV- controls (n=1181) and BAI was compared for the two groups.

Mean chronological age of the HIV+ cohort was 54.9.   In unmatched group comparisons, HIV+ adults had a 5-year elevation in brain age/BAI versus HIV- controls (BAI 5.0 vs. -0.6 years; p-value<0.0001). After matching, the mean HIV+ BAI (+6.5 years) remained higher than HIV- controls (+1.9; mean difference 4.6 years, p-value= 0.001), suggesting that vascular risk factors, common in HIV+ adults, does not fully account for increased brain age in HIV+ adults.  An elevated BAI was seen in 65% of HIV+ cases.

The majority of HIV+ adults on ART had older brain ages than expected for chronological age and predicted to have a 4-year increase in brain age than people without HIV infection. Further work is needed to determine drivers for accentuated brain aging in HIV+ adults on ART.

Authors/Disclosures
Michael J. Leone
PRESENTER
Michael J. Leone has nothing to disclose.
Haoqi Sun, PhD (Massachusetts General Hospital) Dr. Sun has nothing to disclose.
Luis Paixao, BMBCh, MSc No disclosure on file
No disclosure on file
Shibani S. Mukerji, MD, PhD (Massachusetts General Hospital) Dr. Mukerji has stock in Gilead Science. Dr. Mukerji has stock in Ranpack. Dr. Mukerji has stock in Snowflake. An immediate family member of Dr. Mukerji has stock in Amgen. The institution of Dr. Mukerji has received research support from NIH. The institution of Dr. Mukerji has received research support from Massachusetts General Hospital.
M. B. Westover, MD, PhD (MGH) Dr. Westover has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Beacon Biosignals. Dr. Westover has stock in Beacon Biosignals. The institution of Dr. Westover has received research support from NIH. Dr. Westover has received publishing royalties from a publication relating to health care. Dr. Westover has a non-compensated relationship as a cofounder with Beacon Biosignals that is relevant to AAN interests or activities.