好色先生

好色先生

Explore the latest content from across our publications

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Prevalence and Healthcare Resource Utilization of Community-acquired and Nosocomial Bacterial Meningitis Infections in the United States
Infectious Disease
S45 - Neuroinfectious Disease: Treatments, Diagnostics, and Outcomes (1:33 PM-1:44 PM)
004

Although bacterial meningitis is known to be among the top infectious causes of death, there has not been a robust longitudinal study of the associated morbidity, mortality, or economic burden in recent years.

This study examines the healthcare resource utilization (HCRU) in the United States (US) of community-acquired versus nosocomial bacterial meningitis infections and characterizes the relative prevalence of these infections, incidence of ensuing complications, and associated rates of mortality.

The Truven Health MarketScan® Research database was used to identify patients with a bacterial meningitis diagnosis admitted to a hospital in the US between 2008 and 2015. HCRU data was collected for up to 2 years following initial diagnosis. Cost analyses were conducted for patients without head trauma.

5181 patients diagnosed with bacterial meningitis were identified. Of these, 88.0% were adults and 12.0% were pediatric patients (<=18yo). Nosocomial infections comprised 24.8% of bacterial meningitis cases  (main organisms: staphylococcus/MRSA, gram negative, and anaerobic bacteria). Community-acquired infections accounted for 23.5% of cases (main organisms: streptococcus, pneumococcus, and meningococcus). The remainder (51.7%) were other bacterial types (e.g. haemophilus) or were unspecified. Median length of stay for the index admission was 10.0 days (IQR, 5.0 to 19.0 days). The 30-day complication rate for nosocomial infections and community-acquired infections was 38.8% and 27.3%, respectively. The most common complications were hydrocephalus (8.3%), intracranial epidural abscess (7.1%) and intracerebral hemorrhage (6.9%). The 30-day hospital inpatient mortality rate was 4.1% for nosocomial infections and 6.6% for community-acquired infections (p=0.0056). Median 90-day cost for the nosocomial group was $84895.3 (IQR, $38903.1 to $174241.9) versus $51977.80 (IQR, $29290.1 to $107786.4) for the community-acquired group.

Our study characterizes a longitudinal cohort of 5181 bacterial meningitis cases in the US from 2008-2015. The health economic impact, morbidity, and mortality were quantified, demonstrating the substantial HCRU of bacterial meningitis patients in the US.

Authors/Disclosures
Sarah D. Hodges, DO
PRESENTER
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Christopher P. Eckstein, MD The institution of Dr. Eckstein has received research support from Biogen. The institution of Dr. Eckstein has received research support from Genzyme.
No disclosure on file