好色先生

好色先生

Explore the latest content from across our publications

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease
Movement Disorders
S41 - Imaging in Movement Disorders (4:36 PM-4:47 PM)
007

Cognitive impairment in PD often does not respond to dopaminergic therapy suggesting involvement of other neurotransmitter systems or brain regions beyond the nigrostriatal pathway. Most neuroimaging studies of PD have focused on striatal dopaminergic circuitry; this approach may not fully explain cognitive impairment. The cerebellum has reciprocal anatomic connections to motor and association cortex including extrastriate occipital cortex. The cerebellar vermis harbors a rich population of cholinergic neurons; its malfunction could also contribute to cognitive impairments.

The purpose of this study was to investigate the contributions of altered cerebellar resting-state functional connectivity to motor and cognitive impairments in Parkinson disease (PD).

To investigate the role of the cerebellum, we conducted volumetric and resting-state functional connectivity MRI analyses in 81 PD and 43 age-matched healthy controls using rigorous quality assurances measures. Comprehensive measures of cognition were assessed. To calculate group differences based on cognitive status, we contrasted PD participants with normal cognition (Clinical Dementia Rating scale, CDR = 0; n = 47) versus participants with cognitive impairment (CDR ≥ 0.5; n = 34).

No significant differences in cerebellar lobular volumes were observed. The PD group had significantly greater functional connectivity between the vermis and visual association cortex that inversely correlated with visuospatial functions and global cognition. The cognitively impaired PD group had significantly lower functional connectivity between the vermis and dorsolateral prefrontal cortex. This effect correlated with deficits in attention, executive functions and global cognition. There were no behavioral correlates of greater cerebellar-sensorimotor cortex or lower intracerebellar functional connectivity in the PD cohort.

These results demonstrate a contribution of the cerebellar vermis to cognitive impairment in PD. The findings in PD participants with relatively mild degrees of cognitive impairment suggest that vermal functional connectivity may be an early imaging biomarker of subsequent cognitive decline.

Authors/Disclosures
Baijayanta Maiti, MD, PhD (Washington University in St. Louis School of Medicine)
PRESENTER
The institution of Dr. Maiti has received research support from National Center for Advancing Translational Sciences of the NIH . The institution of Dr. Maiti has received research support from National Institute of Neurological Disorders and Stroke (NINDS) / NIH .
No disclosure on file
No disclosure on file
Scott Norris, MD (Washington University School of Medicine) The institution of Dr. Norris has received research support from NIH, DMRF, Dysphonia International.
Meghan C. Campbell, PhD (Washington University in St. Louis) The institution of Meghan C. Campbell has received research support from NIH. The institution of Meghan C. Campbell has received research support from NIH. The institution of Meghan C. Campbell has received research support from McDonnell Center for Systems Neuroscience. The institution of Meghan C. Campbell has received research support from WUSM Radiology Department. The institution of Meghan C. Campbell has received research support from NIH. Meghan C. Campbell has received personal compensation in the range of $0-$499 for serving as a Grant Reviewer with Parkinson Foundation. Meghan C. Campbell has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with Department of Defense.
Joel S. Perlmutter, MD, FAAN (Washington University in St. Louis) Dr. Perlmutter has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for CHDI. Dr. Perlmutter has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Parkinson Study Group. Dr. Perlmutter has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Wood, Cooper and Peterson, LLC . Dr. Perlmutter has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Simmons and Simmons LLP . The institution of Dr. Perlmutter has received research support from NIH. The institution of Dr. Perlmutter has received research support from American Parkinson Disease Association (Advanced Research Center at Washington University). The institution of Dr. Perlmutter has received research support from CHDI. The institution of Dr. Perlmutter has received research support from Huntington Disease Society of America. The institution of Dr. Perlmutter has received research support from University of Western Toronto. The institution of Dr. Perlmutter has received research support from Barnes-Jewish Hospital Foundation. The institution of Dr. Perlmutter has received research support from Michael J Fox Foundation. The institution of Dr. Perlmutter has received research support from UCSD. The institution of Dr. Perlmutter has received research support from Paula & Rodger Riney FUnd. The institution of Dr. Perlmutter has received research support from Jo Oertli Fund. The institution of Dr. Perlmutter has received research support from Murphy FUnd. The institution of Dr. Perlmutter has received research support from Fixel Fund. The institution of Dr. Perlmutter has received research support from N Grant WIlliams Fund. The institution of Dr. Perlmutter has received research support from Pohlman Fund. Dr. Perlmutter has received personal compensation in the range of $500-$4,999 for serving as a lecturer with Boston University. Dr. Perlmutter has received personal compensation in the range of $500-$4,999 for serving as a external advisor with Stanford University. Dr. Perlmutter has received personal compensation in the range of $500-$4,999 for serving as a visiting professor with Beth Israel Hospital. Dr. Perlmutter has received personal compensation in the range of $500-$4,999 for serving as a visiting professor with U Pennsylvania.