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Abstract Details

Patterns of regional changes in thalamic shape and volume are related to performance in specific cognitive domains in Multiple Sclerosis
Multiple Sclerosis
S31 - MS and CNS Inflammatory Disease: Imaging (4:58 PM-5:09 PM)
009

Cognitive impairment (CI) is a common and disabling symptom in MS. Several magnetic resonance imaging (MRI) studies have shown that thalamus, among other gray matter (GM) structures, is the most relevant for cognitive performance in MS.

To assess the relationship between thalamic regional volumes/shape and performance in global/specific cognitive domains in multiple sclerosis (MS).

One hundred and eighteen relapsing remitting MS (RRMS) patients and 52 sex, age and education-matched healthy controls (HC) underwent an extensive neuropsychological assessment, through Brief Repeatable Battery of Neuropsychological Tests (BRB) and Stroop Test, and a 3T–MRI protocol including high resolution 3D–T1 imaging.  Thalamic volumes were calculated using FIRST tool of the FMRIB Software Library. A vertex analysis of thalamic shape was also performed, exploring regional differences between MS and HC. Correlation analyses were run between performance in global/specific cognitive domains and thalamic changes in shape/volume. Thalamic connectivity-defined subregions showing significant changes were labeled using an atlas previously derived that includes probability maps of thalamic parcellation in frontal, motor, parietal, occipital, and temporal connectivity defined regions.

Compared to HC, MS patients showed a significant atrophy (p<0.01) in the whole thalamus. Considering the correlation analyses between global/specific cognitive performance and thalamic volume/shape: 1) attention/information processing speed performance correlated (p<0.01) with atrophy of bilateral frontal-connected and right (R) motor-connected thalamic subregions; 2) verbal fluency performance correlated (p=0.05) with atrophy of  left (L) all thalamus subregions and R frontal/temporal-connected thalamic subregions; 3) executive functions performance correlated (p<0.01)  with atrophy of all thalamus subregions, bilaterally; 4) global cognitive status correlated (p<0.01) with atrophy  of L frontal/temporal-connected subregions.

This study further confirms that the thalamus is relevant for cognitive status in MS. Furthermore, patterns of regional changes in thalamic shape/volume are relevant for performance in specific cognitive domains in MS.

Authors/Disclosures
Alvino Bisecco
PRESENTER
Alvino Bisecco has nothing to disclose.
No disclosure on file
No disclosure on file
Alessandro D'Ambrosio No disclosure on file
No disclosure on file
Simona Bonavita No disclosure on file
No disclosure on file
Antonio Russo, Prof (University of Campania "Luigi Vanvitelli") No disclosure on file
No disclosure on file
Maria A. Rocca (Neuroimaging Research Unit) Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Bristol Myers Squibb, Eli Lilly, Janssen, Roche. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZaneca, Biogen, Bristol Myers Squibb, Bromatech, Celgene, Genzyme, Horizon Therapeutics Italy, Merck Serono SpA, Novartis, Roche, Sanofi and Teva. The institution of Maria Assunta Rocca has received research support from MS Society of Canada, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Gioacchino Tedeschi, MD (University of Campania "L. Vanvitelli") Dr. Tedeschi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Tedeschi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Tedeschi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis.
No disclosure on file
Antonio Gallo Antonio Gallo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. Antonio Gallo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Antonio Gallo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Antonio Gallo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis.