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Abstract Details

Magnetic Resonance Spectroscopy of Sports-related Head Injury: A Cross-Sectional Comparison
Neuro Trauma, Critical Care, and Sports Neurology
S8 - Neuro Trauma and Sports Neurology (4:14 PM-4:25 PM)
005

Concussions and head injuries are a common occurrence in every level of contact sports. It has been estimated that 1.6 to 3.8 million people sustain a sports-related traumatic brain injury. The long-term sequelae of repetitive head impacts (RHI) such as chronic traumatic encephalopathy (CTE) have become a major concern.  MRS provides a non-invasive and quantitative assay that is highly sensitive to even subconcussive injuries.  Furthermore, the alternation of brain metabolites provides insight into the underlying pathophysiological changes that may be occurring with sports-related RHI.  

The aim of this study is to compare the results of magnetic resonance spectroscopy (MRS) studies of repetitive head impacts in sports including American football and European soccer.

15 symptomatic retired NFL athletes with exposure to concussive RHI were compared to 11 age-matched former professional soccer players with exposure to subconcussive RHI and 14 athletes in non-contact competitive sports with no history of RHI.  All athletes underwent single voxel point-resolved spectroscopy in the posterior cingulate gyrus on 3T MRI (Siemens) using the same acquisition parameters.  All data was post-processed using LCmodel to determine metabolite concentrations and ratios.

Choline was found to be significantly increased in both football and soccer players (p<0.05) but myoinositol levels were increased (p<0.005) in soccer players.  Glutamate was normal in soccer players when compared to controls but significantly decreased in football players (p<0.0005).  Surprisingly NAA levels were decreased in athletes but found to be somewhat increased with football players reaching significance (p<0.05). 

These findings show significantly different patterns in brain metabolite levels when comparing concussive and subconcussive injuries that also differ from healthy brain levels.  Subconcussive RHI appears to be more inflammatory with increased glial (myoinositol) and axonal changes (choline) whereas concussive injuries appear to have a greater impact upon neurotransmission (glutamate). 
Authors/Disclosures
Alexander P. Lin, PhD (Brigham and Women'S Hospital/Harvard Med School)
PRESENTER
Prof. Lin has received personal compensation in the range of $0-$499 for serving as a Consultant for Agios Pharmaceuticals. Prof. Lin has received personal compensation in the range of $0-$499 for serving as a Consultant for Biomarin. Prof. Lin has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Moncton MRI. Prof. Lin has stock in BrainSpec, Inc. Prof. Lin has received intellectual property interests from a discovery or technology relating to health care.
Inga K. Koerte, MD, PhD (Ludwig-Maximilians-Universitat) An immediate family member of Prof. Koerte has stock in Siemens Healthineers. The institution of Prof. Koerte has received research support from NINDS. The institution of Prof. Koerte has received research support from Abbott Inc.. The institution of Prof. Koerte has received research support from European Research Council. The institution of Prof. Koerte has received research support from German Ministry of Research and 好色先生 . Prof. Koerte has received publishing royalties from a publication relating to health care. Prof. Koerte has a non-compensated relationship as a Vice President with European Neurotrauma Organization that is relevant to AAN interests or activities. Prof. Koerte has a non-compensated relationship as a European Editor with Journal of Neurotrauma that is relevant to AAN interests or activities.