Overall 30-DR rate was 17% (7140 of 42,655 weighted index admissions) and the median interval to readmission was 10 days. The common causes of readmission were infection (18%), systemic diseases (11.4 %; acute kidney injury, congestive heart failure, respiratory failure), CNS disorders (5.9%), delirium-associated cognitive disorders (4.8%), alcohol-related (2.5%), and aspiration pneumonia (2.2%). Compared to initial (index) hospitalization, readmission had higher mean length-of-stay (LOS; 6.9 vs. 6.1 days, p<0.0001) and hospitalization cost ($12594 vs. $10533, p<0.0001). Independent predictors of readmission included discharge against medical advice (OR 1.9, p< 0.0034), >6 days LOS (OR 1.3, p<0.0001), chronic renal failure (OR 1.4, p<0.0001), CHF (OR 1.3, p<0.0001), chronic lung disease (OR 1.2, p<0.0004), and chronic liver disease (OR 1.2, p<0.03). Having private insurance was associated with a lower risk of readmission (OR 0.78, p<0.02).