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Abstract Details

Myelinating Proteins in MS are Linked to Volumetric Brain MRI changes
Multiple Sclerosis
P6 - Poster Session 6 (11:30 AM-1:00 PM)
9-019

There is evidence of a relationship between pro-myelinating proteins and clinical MS activity during clinical relapse or recovery from clinical relapses.

Examine the linkage between pro-myelinating biomarkers and volumetric changes in multiple sclerosis (MS) subjects during serial magnetic resonance (MR) imaging.

We enrolled 13 MS subjects with active brain MRI scans not on disease modifying therapies (DMTs). Subjects underwent baseline MRI, serum and CSF sampling.  Qualitative changes; new/resolving Gd, new/enlarging/diminishing T2 and T1 hypointense lesions were compared to baseline in subsequent MRI scans, and volumetric analysis was calculated. Analysis of biomarkers on serial CSF samples was performed only in subjects with qualitative (and quantitative) changes on MRI. 

There was increased CSF N-CAM during increased qualitative T1 activity. A positive correlation between CSF and serum N-CAM and T1 lesion volume was observed.   A negative correlation between serum BDNF and BPH and T1 lesion volume was observed.  

Increased N-CAM levels may be related to repair or re-myelination following injury to the brain as shown by increased T1 volumes. Our data suggest an early kind of blood signaling that induces release of peripheral BDNF levels.  

Authors/Disclosures
Staley A. Brod, MD (Staley Brod, MD)
PRESENTER
Dr. Brod has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for EMD Serono. Dr. Brod has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Sanofi.
John A. Lincoln, MD, PhD (McGovern Medical School, UTHealth) The institution of Dr. Lincoln has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi-Genzyme. Dr. Lincoln has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. The institution of Dr. Lincoln has received research support from Deaprtment of Defense. The institution of Dr. Lincoln has received research support from National Institutes of Health. The institution of Dr. Lincoln has received research support from EMD-Serono. Dr. Lincoln has received intellectual property interests from a discovery or technology relating to health care.
Flavia Nelson, MD (University of Miami, Miller School of Medicine) Dr. Nelson has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Brystol Meyer Squib. Dr. Nelson has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Nelson has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Genetech. The institution of Dr. Nelson has received research support from NIH.