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Abstract Details

Progression of Parkinson’s Disease: A Longitudinal MRI Study of Functional Brain Connectome in a Large Cohort of Patients
Movement Disorders
P6 - Poster Session 6 (11:30 AM-1:00 PM)
15-025

Graph theoretical analyses and network science are powerful tools to study functional organization of the brain.

To investigate functional neural pathway organization and changes over-time in patients with Parkinson’s disease (PD) using advanced network-based techniques.

146 PD patients performed clinical and cognitive evaluations and resting-state functional MRI at baseline and every year for 4 years. Hierarchical cluster analysis identified two PD subtypes: 86 “early” and 60 “mild-to-severe” patients. Within the “early” subtype, two clinical groups were identified: “early-motor-predominant” and “early-diffuse”, the latter having greater cognitive deficits and more frequent non-motor manifestations. 60 age- and sex-matched controls performed baseline assessments. Graph analysis and connectomics assessed global and local topological network properties and regional functional connectivity (FC) at baseline and changes over-time.

“Early” PD patients showed a relatively preserved global functional architecture at baseline and over-time. At baseline, “mild-to-severe” patients showed altered functional topological properties of the sensorimotor and parietal areas relative to controls. Longitudinal analysis showed a progressive deterioration of global functional topological features in “mild-to-severe” patients, with a specific involvement of the sensorimotor, frontal, parietal and temporal regions. At baseline, a widespread pattern of decreased FC involving the basal ganglia, sensorimotor, frontal, parietal and temporal networks was found in “mild-to-severe” and “early-diffuse” patients relative to controls and in “mild-to-severe” relative to “early-motor-predominant” cases. When FC changes over-time were compared between subtypes, five distinct patterns of progression were identified: 1) different trend of change between subtypes (increase vs decrease); 2 & 3) similar trend of change (increase or decrease), with or without FC difference between the groups; 4) different but stable FC values over time in the two subtypes; 5) stable FC with no difference between groups.

Graph analysis and connectomics might represent a powerful approach to understand the pathophysiological process associated with PD progression.

Authors/Disclosures
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)
PRESENTER
Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Silvia Basaia Silvia Basaia has nothing to disclose.
No disclosure on file
No disclosure on file
Iva Stankovic (Neurology Clinic, Clinical Center of Serbia, University of Belgrade) Iva Stankovic has nothing to disclose.
No disclosure on file
No disclosure on file
Elka Stefanova No disclosure on file
Vladimir S. Kostic, MD, PhD (Institute of Neurology CCS) Dr. Kostic has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Roche. An immediate family member of Dr. Kostic has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Alkaloid. The institution of Dr. Kostic has received research support from Ministry of 好色先生, Science and Technological Development of Serbia.
Federica Agosta (San Raffaele Scientific Institute) Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.