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Abstract Details

Functional Network Connectivity Predicts Spreading of Cortical Atrophy in Parkinson’s Disease
Movement Disorders
P6 - Poster Session 6 (11:30 AM-1:00 PM)
15-026

The neurodegenerative process in PD moves along neural networks, possibly reflecting the spread of toxic alpha-synuclein molecules.

To decipher the mechanisms of network-based neurodegeneration in Parkinson’s disease (PD) investigating the relationship between functional network connectivity (FC) in healthy brain connectome and cortical thinning in patients at the early disease stage, and to develop a predictive model for atrophy spreading in PD.

86 early-stage PD patients performed 3D T1-weighted MRI at baseline and every year for 3 years. Resting state functional MRI (rs fMRI) was obtained from 60 age- and sex-matched controls at baseline.The brain was parcellated into 83 regions. Mean volumes for each region were calculated for PD patients and controls on 3D T1-weighted images. Regional percentage of atrophy in PD patients relative to controls was calculated at each time point: [1-(mean patient volumes/mean control volumes)]*100. Functional healthy connectome was estimated from rs fMRI in controls. In PD patients, the “disease exposure” (DE) to pathology of each brain region at each time point was defined as a function of FC of the region with the whole brain in healthy connectome and the severity of atrophy of the connected regions (i.e., the sum of the products of FC between i and all the other brain regions j in healthy subjects and atrophy percentage of the corresponding region j in patients). DE during the first and second year of follow up was used to predict atrophy at the subsequent time points.

In early-stage PD patients, regional DE at 1-year follow-up predicted atrophy accumulation at 2-year follow-up relative to baseline. Although atrophy at 3 years was increased relative to 2-year follow-up, its variation did not correlate with DE at any time point.

Our study suggests that disease propagation in PD follows functional network connectivity. 

Authors/Disclosures
Federica Agosta (San Raffaele Scientific Institute)
PRESENTER
Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
Silvia Basaia Silvia Basaia has nothing to disclose.
No disclosure on file
No disclosure on file
Iva Stankovic (Neurology Clinic, Clinical Center of Serbia, University of Belgrade) Iva Stankovic has nothing to disclose.
No disclosure on file
No disclosure on file
Elka Stefanova No disclosure on file
Vladimir S. Kostic, MD, PhD (Institute of Neurology CCS) Dr. Kostic has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Roche. An immediate family member of Dr. Kostic has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Alkaloid. The institution of Dr. Kostic has received research support from Ministry of 好色先生, Science and Technological Development of Serbia.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit) Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.