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Abstract Details

New Evidence from the Italian chROnic migraiNe Registry (IRON Registry): An Update on 866 Patients
Headache
S1 - Headache 1 (1:12 PM-1:24 PM)
002

The IRON Registry, launched in 2014, is aimed to disentangle chronic migraine (CM) endophenotypes and to assess patient’s journey, treatment and health care resource use. 

To provide and update of the Italian chROnic migraiNe registry (IRON Registry)

We enrolled all consecutive CM outpatients visited in 24 Italian headache centers from 01/3/2018 to 10/10/2019. Detailed information were gathered with face-to-face interviews using a shared semi-structured web-based questionnaire.

Ninety hundred and thirty-two CM patients were enrolled. Our interim analysis refers to 866 patients (females: 84%; age: 46.4 yrs; monthly headache frequency: 27.7±16.1days). In CM patients, episodic migraine onset occured at the age of 17.4  yrs while chronicization at 35.3 yrs. First headache specialist consultation occurred at the age of 35.3 yrs. Only 23.5% of CM patients used a prophylaxis when migraine was episodic. 

Access to the emergency department during the previous 12 months occurred in 25.3% of patients. Most migraineurs (76.3%) underwent multiple investigations mostly inappropriate (78.1%) and loaded on the national health system (59.6%). Each patient had consulted 8.3+14.5 different specialists for their migraine. Only 1.8% had a disability allowance. 

Patients with near daily CM (≥ 25 days/month) differed from the other chronic migraineurs for younger age at CM onset (p= 0.032), more frequent bilateral pain (p = 0.006), lower triptan (p= 0.04) and higher analgesic use (p < 0.000), lower headache diary use (p <0.000), poorer pharmacological compliance (p= 0.004), more frequent hospitalization (p= 0.045) and emergency department access (p= 0.006). 

Our study reveals low disease awareness and major issues in CM patient’s journey which result in delayed treatment and a considerable burden for our national health system. In particular we document late headache center referral and inappropriate diagnostic and therapeutic strategies. Patients with near daily CM show substantial clinical differences from other CM patients. 

Authors/Disclosures
Piero Barbanti, MD
PRESENTER
Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie. Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli-Lilly. Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for TEVA. Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Fondazione Ricerca e Salute. Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lundbeck. Dr. Barbanti has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Visufarma. Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Assosalute. Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer. Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eli-Lilly. Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Organon. Dr. Barbanti has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Barbanti has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for TEVA. Dr. Barbanti has received publishing royalties from a publication relating to health care.
No disclosure on file
No disclosure on file
No disclosure on file
Licia Grazzi, MD (Neurological Institute C Besta) Dr. Grazzi has received personal compensation in the range of $0-$499 for serving as a Consultant for EliLilly. Dr. Grazzi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for allergan-abbvie.
Fabrizio Vernieri No disclosure on file
No disclosure on file
No disclosure on file
Paola Torelli No disclosure on file
Sabina Cevoli Sabina Cevoli has nothing to disclose.
Antonio Russo, Prof (University of Campania "Luigi Vanvitelli") No disclosure on file
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Stefano Messina, MD (Istituto Auxologico Italiano, Ospedale San Lu) No disclosure on file
No disclosure on file
No disclosure on file
Marco Aguggia No disclosure on file
Fabio Frediani No disclosure on file
No disclosure on file
Massimo Autunno No disclosure on file
No disclosure on file
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Francesco Perini No disclosure on file
No disclosure on file
No disclosure on file
Bruno Colombo Bruno Colombo has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file