A total of 446,446 US hospitalizations had a primary diagnosis of migraine. Out of these, 130,914(29.32%) patients had SM. There was a significant increase in the prevalence of SM in the migraineurs (2003:27.49% to 2014:32.68%;pTrend<0.0001). Patients with SM tend to be younger (median age 40-year vs. 44-year), females(85.86%vs.78.31%;p<0.0001), and whites(81.83%vs.70.31;p<0.0001), compared to patients without SM. On weighted analysis, drug abuse (4.76%vs.3.93%;aOR=1.13;95%CI=1.03-1.24), vitamin D deficiency (0.70%vs.0.53%;aOR=1.28;95%CI=1.05-1.56), opioid abuse (1.76%vs.0.99%;aOR=1.43;95%CI=1.22-1.68), organic sleep disorders (3.41%vs.3.06%;aOR=1.38;95%CI=1.26-1.50), medication overuse headache (1.66%vs.0.28%;aOR=3.63;95%CI=2.95-4.45), generalized anxiety disorder (1.36%vs.0.63%;aOR=1.50;95%CI=1.28-1.77), major depression disorder (29.03%vs.19.26%;aOR=1.56;95%CI=1.50-1.62), and post-traumatic stress disorder (1.90%vs.1.21%;aOR=1.37;95%CI=1.21-1.55) were associated with higher prevalence and odds of SM. SM patients had higher prevalence and odds of morbidity (1.20%vs.0.98%;aOR=1.67;95%CI=1.43-1.96) compared to patients without SM. Acute ischemic stroke (aOR=2.60;95%CI=1.34-5.07), hemorrhagic stroke (aOR=7.07;95%CI=1.94-25.72), obesity (aOR=1.47;95%CI=1.22-1.78), atrial fibrillation (aOR=1.62;95%CI=1.19-2.20), renal failure(acute/chronic/end-stage) (aOR=1.38;95%CI=1.04-1.83), epilepsy (aOR=2.31;95%CI=1.88-2.82), generalized anxiety disorder (aOR=1.78;95%CI=1.02-3.11), major depression disorder (aOR=1.38;95%CI=1.19-1.61), and post-traumatic stress disorder (aOR=1.74;95%CI=1.15-2.66) were associated with higher morbidity in SM patients.