Abstract Details

Title Regional Brain Volumes Associated with Neurocognitive Performance in Zambian Youth with Human Immunodeficiency Virus

Topic Infectious Disease

Presentation(s) S28 - Infectious Disease: Chronic Meningitis and the Immunosuppressed (2:12 PM-2:24 PM)

Poster/Presentation
Number 007

Background Cognitive impairment is common in children and adolescents with HIV. Brain MRI imaging is a potentially useful tool to understand the pathophysiology of cognitive impairment. There are few imaging studies of children with HIV in sub-Saharan Africa.

Objective To identify brain regions associated with test performance in eight cognitive domains commonly affected by human immunodeficiency virus (HIV): Response inhibition, set shifting, attention, processing speed, immediate recall, verbal fluency, nonverbal reasoning, and motor speed.

Design/Methods Thirty-four perinatally infected subjects with HIV between the ages nine and 17 years were recruited from Lusaka, Zambia as part of the HIV-associated Neurocognitive Disorders in Zambia (HANDZ) study. Subjects underwent comprehensive neuropsychological testing and brain MRI imaging. Brain segmentation and volumetric analyses were conducted using FreeSurfer. 123 cortical and subcortical brain regions were evaluated for each MRI. Multiple linear regression was used to evaluate the association between regional volumes with the eight population-normed neuropsychological test scores controlling for age and sex. False discovery rate due to multiple comparisons was controlled for using the Benjamini-Hochberg procedure.

Results Associations between the right lingual gyrus volume and processing speed (P=0.006) and immediate recall (P=0.002) were identified as were associations between bilateral cerebellar white matter volumes and immediate recall (right, left P=0.001, 0.008), verbal fluency (P=0.005, 0.002) and non-verbal reasoning (P=0.0006, 0.005).

Conclusions Regional brain volumes may be biomarkers of domain-specific cognitive function in Zambian youth with HIV. The association of cerebellar volumes with cognitive performance in these domains requires further investigation and may suggest selective vulnerability of the cerebellum to HIV-associated injury.

Authors/Disclosures
Owen Dean PRESENTER	No disclosure on file
Alexandra Buda	Ms. Buda has nothing to disclose.
Heather Adams	The institution of Heather Adams has received research support from Current: NIH; Past: Abeona; Batten Research Alliance; American University Centers on Disabilities. An immediate family member of Heather Adams has received publishing royalties from a publication relating to health care. Heather Adams has received personal compensation in the range of $500-$4,999 for serving as a Consultant with Critical Path Institute.
Sylvia Mwanza-Kabaghe	No disclosure on file
Michael Potchen	Michael Potchen has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Jackson & Campbell, P.C.. Michael Potchen has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Rotezel & Andress.
Esau G. Mbewe	Esau G. Mbewe has received research support from Research was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number K23NS117310. .
Pelekelo Kabundula	Pelekelo Kabundula has nothing to disclose.
	No disclosure on file
Gretchen L. Birbeck, MD, MPH, DTMH, FAAN (University of Rochester/CHET)	An immediate family member of Dr. Birbeck has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Various. Dr. Birbeck has a non-compensated relationship as a Ambassador for Zambia with RSTMH that is relevant to AAN interests or activities.
David Bearden, MD (University of Rochester School of Medicine)	Dr. Bearden has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Bearden has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Praxis. Dr. Bearden has received personal compensation in the range of $100,000-$499,999 for serving as an Expert Witness for law firms.

��ɫ��

��ɫ��