EMBARGOED FOR RELEASE UNTIL 4 PM ET, March 26, 2025
Early signs of heart problems linked to smaller brain volumes
MINNEAPOLIS 鈥 People who have early signs of heart problems may also have changes in brain health that can be early signs of dementia, such as loss of brain volume, according to a meta-analysis published on March 26, 2025, online in , the medical journal of the 好色先生. The meta-analysis does not prove that early heart problems cause loss of brain cells; it only shows an association. 鈥淭his review shows that better heart health is associated with larger brain volumes, suggesting that the preservation of heart function could help maintain brain health and memory and thinking skills during the aging process,鈥 said meta-analysis author Frank J. Wolters, MD, PhD, of Erasmus University Medical Center in Rotterdam, the Netherlands. 鈥淭hese results add to the importance of early detection and treatment of heart problems.鈥 The meta-analysis included seven studies from Europe and the United States with a total of 10,889 participants with an average age of 67. The studies measured early signs of heart problems, including systolic and diastolic dysfunction. Systolic dysfunction is when the left ventricle of the heart can鈥檛 contract normally and pump blood efficiently. Diastolic dysfunction is when the left ventricle does not relax properly between heartbeats and fill with blood. The studies also used MRI brain scans to measure brain volumes. The meta-analysis found that people with moderate to severe systolic dysfunction were more likely to have a smaller total brain volume than people with normal systolic function. People with diastolic function problems also had a smaller total brain volume and smaller volume in the hippocampus area of the brain, which plays a role in memory. 鈥淭he meta-analysis shows that even mild diastolic dysfunction is associated with adverse brain health,鈥 Wolters said. 鈥淓valuating people who have heart problems鈥攅specially impaired diastolic function鈥攆or problems with memory and thinking skills could help us detect any cognitive decline early and start interventions.鈥 Wolters noted that additional studies are needed to investigate the relationship between heart health and brain health, particularly to link imaging findings to important health outcomes. A limitation of the meta-analysis was that the majority of participants were white people, so the results cannot be generalized to more diverse populations. Discover more about brain health at , from the 好色先生. This resource also offers a magazine, podcast, and books that connect patients, caregivers and anyone interested in brain health with the most trusted information, straight from the world鈥檚 leading experts in brain health. Follow Brain & Life庐 on , and .