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Press Release

EMBARGOED FOR RELEASE UNTIL 4 PM ET, January 06, 2010

Study: New Brain Scan Better Detects Earliest Signs of Alzheimer鈥檚 Disease in Healthy People

ST. PAUL, Minn. -

A new type of brain scan, called diffusion tensor imaging (DTI), appears to be better at detecting whether a person with memory loss might have brain changes of Alzheimer鈥檚 disease, according to a new study published in the January 6, 2010, online issue of , the medical journal of the . 鈥淎s better medicines for Alzheimer鈥檚 disease become available, it will be important to identify people at high risk for the disease as early and accurately as possible so treatment can be most effective,鈥 said Norbert Schuff, PhD, with the University of California and the Veterans Affairs Medical Center, San Francisco, author of an editorial about the research. For the study, 76 healthy people in Rome aged 20 to 80 underwent DTI-MRI brain scanning, which is more sensitive than traditional MRI for detecting changes in brain chemistry, thereby mapping fiber tracts that connect brain regions. The researchers examined DTI changes in the hippocampus, a region of the brain that is critical to memory and one that is involved in Alzheimer鈥檚 disease. Participants were given verbal tests and tests that measured visual perception of space between objects. Scientists compared the brain scans and found that changes in DTI imaging better explained declines in memory than did measuring hippocampus volume through a traditional MRI. They found that mean diffusivity in the hippocampus better predicted verbal and spatial memory performance in the participants, especially in those who were 50 years of age or older. 鈥淥ur findings show this type of brain scan appears to be a better way to measure how healthy the brain is in people who are experiencing memory loss. This might help doctors when trying to differentiate between normal aging and diseases like Alzheimer鈥檚,鈥 said study author Giovanni Carlesimo, PhD, with Tor Vergata University in Rome, Italy. 鈥淒TI, along with MRI, could serve as an important tool in understanding how and why a person experiences memory decline.鈥 The study was supported by the Italian Ministry of Health.

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