1. Decreased mRNA and protein amount of GSTO1 gene in patients with muscle disease.
2. Protein amount of GstO2 in muscle tissue significantly decreases as aging progresses.
In fruit flies, it is suggested that the function of GstO2 may be important in the process of muscle cell damage due to aging.
3. We build a GSTO1/GstO2 RNAi fruit fly model that can specifically control expression in muscle tissue.
4. The results of GSTO1 reduction in various muscle diseases and GstO2 expression in aging fruit fly muscles indicate that GSTO1/GstO2 may play an important role in the stability and survival of muscle cells.
5. The reduction/inactivation of GSTO1/GstO2 in muscle cells in the development of muscle disease including sarcopenia due to aging is important for mitophage control.
6. GstO2 Restored Defective Locomotive Activity in Motor Neuron-Specific hTDP-43-Induced Flies.