Too elucidate the trends in stroke-related mortality among HIV patients in the US over two decades, stratified by race and gender.

Data from the CDC-WONDER database was analyzed from 1999 to 2020 to assess stroke-related mortality rates among HIV patients. Age-adjusted mortality rates were calculated, and trends were analyzed . The analysis was stratified by race and gender.

 Stroke-related mortality among HIV patients showed a significant initial decline from 1999 to 2001 with an Annual Percent Change (APC) of -21.57% (p<0.05), followed by a more gradual decline from 2001 to 2018 (APC = -1.16%, p<0.05). There was a marked increase in mortality rates from 2018 to 2020 (APC = 22.32%, p<0.05). For Black/African American patients, the mortality rate continued to decline until 2014 (APC = -2.67%, p<0.05). Post-2014, an increasing trend was observed (APC = 3.88%, p<0.05). In contrast, White patients experienced a stable period until 2018 (APC = -0.58%, p<0.05). However, a significant increase was observed between 2018 and 2020 (APC = 31.16%, p<0.05). Among male HIV patients, mortality rates declined significantly from 1999 to 2001 (APC = -18.32%, p<0.05) and continued to decrease until 2012 (APC = -2.56%, p<0.05). A slight increase was observed from 2012 to 2020 (APC = 4.39%, p<0.05). Female patients exhibited a similar trend with an initial decline from 1999 to 2001 (APC = -16.57%, p<0.05), followed by a steady decline until 2018 (APC = -2.34%, p<0.05).

While overall stroke-related mortality among individuals with HIV has decreased over the past two decades, significant racial and gender disparities persist. The mortality rates among African Americans with HIV emphasize are alarmingly high.