Abstract Details

Title The Relationship Between Deep Medullary Veins and Cognition: A Large-Scale Longitudinal Study in a Community Population

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S30 - Stroke Risk Factors, Outcomes, and Prevention (5:18 PM-5:30 PM)

Poster/Presentation
Number 010

Background Pathological changes in cerebral small veins have attracted attention due to their potential link with neurodegenerative diseases. Previous cross-sectional studies have hinted at a relationship between small vein disease and cognitive function. However, the progression of brain structural damage related to small vein disease and its contribution to cognitive decline remains unclear.

Objective To investigate the relationship between deep medullary veins (DMVs) and overall cognitive function, the incidence and progression of cognitive events, and the mediating role of brain structural features in these associations.

Design/Methods This study followed a large community cohort over four years. Participants underwent neuropsychological assessments, including the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and other cognitive tests. The number of DMVs was visually evaluated on SWI images. Structural brain changes were measured using SPM and FreeSurfer, while DTI parameters were derived using FSL. Plasma levels of Aβ40, Aβ42, and BACE1 were analyzed. Multivariate linear and logistic regression analyses were conducted to examine the relationship between DMVs and cognitive function, while mediation models were used to explore the role of brain structural damage in these associations.

Results A total of 1,040 participants were included (mean age 55.98 years, 36.28% male), with 895 completing follow-up assessments. DMV reduction was significantly associated with an increased risk of dementia (OR=0.683, 95%CI=0.500-0.934). DMV reduction was also linked to poorer verbal fluency (β=0.65, SE=0.17, P<0.001), independent of age, sex, education, and vascular risk factors. White matter microstructural damage partially mediated the DMV-executive function relationship, with indirect effects significant at P=0.03.

Conclusions DMV reduction is associated with executive function decline, mediated by white matter microstructural damage, highlighting a potential mechanism for subcortical cognitive impairment. Further research combining vein pathology, brain structure, and cognition is warranted to elucidate the mechanisms of small vein disease.

Authors/Disclosures
Chengqian Li, MD, PhD (Peking Union Medical College Hospital) PRESENTER	Dr. Li has nothing to disclose.
Zi-Yue Liu	Zi-Yue Liu has nothing to disclose.
Feifei Zhai	No disclosure on file
Dong-Hui Ao	No disclosure on file
Fei Han	Fei Han has nothing to disclose.
Mingli Li	No disclosure on file
Jing Yuan (Peking Union Medical College Hospital)	No disclosure on file
Lixin Zhou	Lixin Zhou has nothing to disclose.
Jun Ni	Jun Ni has nothing to disclose.
Ming Yao	Ming Yao has nothing to disclose.
Shu-Yang Zhang	No disclosure on file
Liying Cui, PhD (Peking Union Medical College Hospital)	No disclosure on file
Zhengyu Jin	No disclosure on file
Yi-Cheng Zhu, MD, PhD (Peking Union Medical College Hospital)	Dr. Zhu has nothing to disclose.

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