Abstract Details

Title Lesion Network Mapping of Domains of Intellectual Functioning in Perinatal Strokes

Topic Child Neurology and Developmental Neurology

Presentation(s) S31 - Hot Topics in Child Neurology (4:54 PM-5:06 PM)

Poster/Presentation
Number 008

Background Perinatal stroke, occurring between 20 weeks gestation and 28 days after birth, can cause a range of cognitive, language, and visuospatial deficits. However, despite the impact these deficits can have on patients and their families, the ability to predict individual clinical outcomes is still limited.

Objective To identify specific brain networks associated with cognitive domains leveraging perinatal stroke data.

Design/Methods We analyzed data from 47 perinatal stroke patients with Wechsler Intelligence Scale for Children (WISC), a subset of an identified cohort from our institution (Wu et al. 2023). Lesions were manually segmented, and then registered to a standard template. We then generated maps of functional connectivity for each lesion by leveraging resting state data from 1000 healthy nine-year-olds. We then statistically analyzed patterns of lesion-connectivity based on general intellectual ability (Full Scale IQ), as well as verbal comprehension (VC), visual-spatial reasoning (VS), fluid reasoning (FR), working memory (WM), and processing speed (PS), while controlling for lesion size (FWE p<0.005).

Results While stroke location varied, cognitive abilities characterized by WISC scores were associated with distinct connectivity patterns. FSIQ was correlated with lesion-connectivity to the dorsal Anterior Cingulate Cortex, as were VC, WM, and PS. VC and WM displayed similar patterns, with connectivity to the cerebellum, insula, and somatosensory cortex. FR and PS also showed connectivity to the anterior insula. Of note, the connectivity patterns related to VS were sparse, however, there was significant connectivity to the bilateral cerebellar crus I.

Conclusions Interestingly, there was a positive correlation between lesion-connectivity to these regions and their respective domain subscores, implying that when lesions occur in locations connected to these regions, specific cognitive domains are relatively spared compared to other domains. We plan to test the ability of the connectivity to these networks to predict performance on domain-specific assessments.

Authors/Disclosures
Shreya Tripathy PRESENTER	Ms. Tripathy has nothing to disclose.
Clara Steeby	Ms. Steeby has nothing to disclose.
Gillian Miller (Boston Children's Hospital)	Ms. Miller has nothing to disclose.
Alexander L. Cohen, MD, PhD, FAAN (Boston Children's Hospital)	The institution of Dr. Cohen has received research support from NIH. The institution of Dr. Cohen has received research support from Simons Foundation.
Laura L. Lehman, MD (Boston Children'S Hospital)	The institution of Dr. Lehman has received research support from Children's Tumor Foundation . Dr. Lehman has received personal compensation in the range of $500-$4,999 for serving as a Consultant with Clinical Neurology Society of America.

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