Abstract Details

Title Differences in Cortical Morphology between Migraineurs with and without Photophobia

Topic Headache

Presentation(s) S35 - Hot Topics in Headache (2:24 PM-2:36 PM)

Poster/Presentation
Number 008

Background

Previous studies have shown significant differences in dynamic resting-state functional connectivity in regions such as the right medial orbitofrontal cortex, right lingual gyrus, and left supramarginal gyrus between patients with migraine with photophobia and those without. However, morphological differences in these regions remain unclear.

Objective

To evaluate differences in cortical morphology between patients with migraine with and without photophobia.

Design/Methods Ten patients with migraine and photophobia (without phonophobia or osmophobia) and ten patients with migraine without sensory sensitivities underwent 3T MRI during the interictal phase. T1-weighted structural images were acquired using an accelerated sagittal inversion recovery fast spoiled gradient echo sequence. Gray matter volume, cortical surface area, and cortical thickness were compared using surface-based morphometry (FreeSurfer software). The study was approved by the Institutional Review Board, and all participants provided written informed consent.

Results Significant increases in gray matter volume were observed in the right medial orbitofrontal cortex (p = 0.014), right pars triangularis (p = 0.027), right supramarginal gyrus (p = 0.006), and left rostral anterior cingulate cortex (p = 0.006) in the photophobia group. Surface area increases were found in the right lingual gyrus (p = 0.049), right pericalcarine cortex (p = 0.021), right supramarginal gyrus (p = 0.006), and left postcentral gyrus (p = 0.010). Decreased cortical thickness was noted in the right postcentral gyrus (p = 0.027), right superior parietal lobule (p = 0.043), and left supramarginal gyrus (p = 0.008) in the photophobia group.

Conclusions The observed structural changes in regions such as the right medial orbitofrontal cortex, right lingual gyrus, and left supramarginal gyrus—which previously showed altered functional connectivity—suggest that morphological alterations may underlie the disrupted connectivity. These findings enhance our understanding of the neural mechanisms underlying photophobia in migraine.

Authors/Disclosures
Noboru Imai (Japanese Red Cross Shizuoka Hospital) PRESENTER	Noboru Imai has received personal compensation for serving as an employee of Sawai . Noboru Imai has received personal compensation for serving as an employee of Daiichi Sankyo, Eli Lilly, Otsuka, and Amgen. Noboru Imai has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sawai. Noboru Imai has received personal compensation in the range of $1,000,000+ for serving on a Speakers Bureau for Daiichisankyo, Otsuka, Eli-Lilly, Amgen.
Asami Moriya, MD	Dr. Moriya has nothing to disclose.
Eiji Kitamura	Eiji Kitamura has nothing to disclose.

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