2025 Annual Meeting | S4 - Movement Disorders: Basic Science

Date Sunday 04/06/25

Time 01:00 PM - 03:00 PM PDT Add To Calendar

Location San Diego Convention Center | 29A

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Scientific Platform Session

Moderator(s) Marie Y. Davis, MD, PhD, Hwai Y. Ooi, MD

Topic(s) Movement Disorders

CME Available 2.00 CME credits

Program Materials Program Evaluations

Event Timeline
01:00 PM - 01:24 PM PDT	Speaker	2025 Movement Disorders Research Award: This award recognizes an individual for outstanding work in the field of Parkinson's disease or other movement disorders for either a single outstanding contribution or for lifetime achievement Janis M. Miyasaki, MD, MEd, FAAN
01:24 PM - 01:36 PM PDT	Abstract	003 - Alpha-synuclein in Blood RBC Extracellular Vesicles is Elevated in Parkinson’s Disease and Correlates with Motor Symptom Severity Ergun Y. Uc, MD
01:36 PM - 01:48 PM PDT	Abstract	004 - The FGF14-SCA27B GAA•TTC Repeat Shows a Marked Somatic Expansion Bias in the Cerebellum David Pellerin, MD
01:48 PM - 02:00 PM PDT	Abstract	005 - Evaluation Of Additive Neuroprotective Effect of Combination Therapy For Parkinson's Disease Using in Vitro Models Alexander Shtilbans, MD, PhD, FAAN
02:00 PM - 02:12 PM PDT	Abstract	006 - BHV-8000, a Selective Brain-penetrant TYK2/JAK1 Inhibitor in Development for Neuroinflammatory and Neurodegenerative Diseases, Demonstrates Efficacy in an Alpha-Synuclein Overexpressing Parkinson’s Disease Mouse Model Lindsey L. Lair, MD, FAAN
02:12 PM - 02:24 PM PDT	Abstract	007 - Compound 2a Protects Against Dopaminergic Neuronal Degeneration in a Mouse Model of Parkinson’s Disease Michele Persico, MD
02:24 PM - 02:36 PM PDT	Abstract	008 - Elucidating the Mechanism of p.G192R RAB39B in X-linked Parkinson’s Disease Oswaldo Lorenzo Betancor, PhD
02:48 PM - 03:00 PM PDT	Abstract	010 - The Source and Pathogenic Potential of Blood-derived Alpha-Synuclein George Kannarkat

Faculty Disclosures
Marie Y. Davis, MD, PhD	Dr. Davis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. The institution of Dr. Davis has received research support from NIH NINDS. The institution of Dr. Davis has received research support from University of Washington Institute for Stem Cell and Regenerative Medicine. The institution of Dr. Davis has received research support from VA BLRD. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving as a study section grant reviewer with NIH. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with Parkinson's Foundation.
Hwai Y. Ooi, MD	Dr. Ooi has nothing to disclose.
Janis M. Miyasaki, MD, MEd, FAAN	Dr. Miyasaki has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for ��ɫ��. Dr. Miyasaki has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Oxford University Press. The institution of Dr. Miyasaki has received research support from PCORI. The institution of Dr. Miyasaki has received research support from Brain Canada. The institution of Dr. Miyasaki has received research support from Canadian Consortium on Neurodegeneration in Aging. The institution of Dr. Miyasaki has received research support from University Hospital Foundation. The institution of Dr. Miyasaki has received research support from Social Science and Health Research Council.
Ergun Y. Uc, MD	An immediate family member of Dr. Uc has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for American Board of Pediatrics. The institution of Dr. Uc has received research support from Department of Veterans Affairs. The institution of Dr. Uc has received research support from Department of Defense. The institution of an immediate family member of Dr. Uc has received research support from NIH. The institution of Dr. Uc has received research support from NIH. The institution of Dr. Uc has received research support from NIH. The institution of Dr. Uc has received research support from Parkinson's Foundation. The institution of Dr. Uc has received research support from NIH.
Patrick Aro, MS	Mr. Aro has nothing to disclose.
Michelle E. Lenz, RN	Ms. Lenz has received personal compensation for serving as an employee of VA Research Foundation.
Christina Weber	Christina Weber has nothing to disclose.
Jeffrey Dawson	Jeffrey Dawson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for iotaMotion. Jeffrey Dawson has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Congress of Neurological Surgeons. The institution of Jeffrey Dawson has received research support from Department of Veterans Affairs. The institution of Jeffrey Dawson has received research support from NIH.
Vellareddy Anantharam, PhD	Dr. Anantharam has nothing to disclose.
Anumantha G. Kanthasamy	Anumantha G. Kanthasamy has received personal compensation for serving as an employee of Probiome Therapeutics. Anumantha G. Kanthasamy has received personal compensation in the range of $500-$4,999 for serving as a Consultant for National Institute of Health. Anumantha G. Kanthasamy has stock in Google, meta and Amazon. The institution of Anumantha G. Kanthasamy has received research support from NIH , DoD and MJFF. Anumantha G. Kanthasamy has received intellectual property interests from a discovery or technology relating to health care. Anumantha G. Kanthasamy has received personal compensation in the range of $500-$4,999 for serving as a Consultant with NIH.
Min Shi, PhD	The institution of Dr. Shi has received research support from NIH. The institution of Dr. Shi has received research support from DoD.
Alice Chen-Plotkin, MD	Dr. Chen-Plotkin has received intellectual property interests from a discovery or technology relating to health care.
George Kannarkat	Dr. Kannarkat has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint Global.
Robert Skrinak	No disclosure on file
Travis Unger	Mr. Unger has nothing to disclose.
Thomas F. Tropea, DO	Dr. Tropea has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bial. The institution of Dr. Tropea has received research support from NINDS. The institution of Dr. Tropea has received research support from Parkinson Foundation. The institution of Dr. Tropea has received research support from Michael J Fox Foundation.
Kelvin Luk	The institution of Kelvin Luk has received research support from National Institutes of Health. The institution of Kelvin Luk has received research support from Michael J. Fox Foundation. The institution of Kelvin Luk has received research support from Teva Pharmaceuticals.
Virginia Lee, PhD	Virginia Lee, PhD has nothing to disclose.
Rebecca Zack	Rebecca Zack has nothing to disclose.
Tal Gilboa	No disclosure on file
David R. Walt, PhD	No disclosure on file
Dmitry Ter-Ovanesyan, PhD	Dr. Ter-Ovanesyan has received intellectual property interests from a discovery or technology relating to health care.
Caroline A. Lewis	Ms. Lewis has nothing to disclose.
Michele Persico, MD	Dr. Persico has nothing to disclose.
Tracy-Shi Zhang Fang, PhD	Dr. Fang has nothing to disclose.
Simona Eleuteri	Simona Eleuteri has received intellectual property interests from a discovery or technology relating to health care.
David K. Simon, MD, PhD	Dr. Simon has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Bial Biotech. An immediate family member of Dr. Simon has stock in Biogen. The institution of Dr. Simon has received research support from Weston Brain Institute. The institution of Dr. Simon has received research support from NIH. The institution of Dr. Simon has received research support from Neuraly. Dr. Simon has received personal compensation in the range of $5,000-$9,999 for serving as a Steering Committee Member: SPARK clinical study with Biogen. Dr. Simon has received personal compensation in the range of $500-$4,999 for serving as a Steering Committee Member: NILO-PD clinical study with Michael J Fox Foundation.
Chris Liang, PhD	Dr. Liang has received personal compensation for serving as an employee of Highlightll. Dr. Liang has received personal compensation in the range of $5,000-$9,999 for serving as an officer or member of the Board of Directors for Highlightll. Dr. Liang has stock in Highlightll. Dr. Liang has received intellectual property interests from a discovery or technology relating to health care.
Wei Tang, PhD	Dr. Tang has nothing to disclose.
Bavani Shankar	Ms. Shankar has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Transcenta Therapeutics.
Bruce D. Car	Dr. Car has received personal compensation for serving as an employee of Biohaven Pharmaceuticals. Dr. Car has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for PathAI. Dr. Car has stock in BHVN. Dr. Car has received intellectual property interests from a discovery or technology relating to health care.
Irfan Qureshi, MD	Dr. Qureshi has received personal compensation for serving as an employee of Biohaven. Dr. Qureshi has stock in Biohaven Pharmaceuticals.
Nick Kozauer	Dr. Kozauer has received personal compensation for serving as an employee of Biohaven. Dr. Kozauer has stock in Biohaven.
Vlad Coric	No disclosure on file
Alexander Shtilbans, MD, PhD, FAAN	Dr. Shtilbans has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Kyowa Kirin. Dr. Shtilbans has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Amneal Pharmaceuticals. The institution of Dr. Shtilbans has received research support from NIH. The institution of Dr. Shtilbans has received research support from Praxis Precision Medicines.
Wolfgang Reintsch, PhD	Mr. Reintsch has nothing to disclose.
Andrea Krahn	Ms. Krahn has nothing to disclose.
Valerio E. Piscopo, PhD	Dr. Piscopo has nothing to disclose.
Elise Esneault, PhD	Dr. Esneault has received personal compensation for serving as an employee of Porsolt.
Florian Simon, MSc	Mr. SIMON has nothing to disclose.
Joe Mazzulli, PhD	Dr. Mazzulli has stock in Lysosomal Therapeutics Inc.
Drew Quiriconi	Mr. Quiriconi has nothing to disclose.
Dror M. Rom	Dr. Rom has nothing to disclose.
Thomas M. Durcan, PhD	Dr. Durcan has nothing to disclose.
David Pellerin, MD	Dr. Pellerin has nothing to disclose.
Jean-Loup Méreaux, MD	The institution of Dr. Méreaux has received research support from Fondation pour la Recherche Médicale FRM. The institution of Dr. Méreaux has received research support from Biogen.
Susana Boluda	Susana Boluda has nothing to disclose.
Matt Danzi	Matt Danzi has nothing to disclose.
Marie-Josee Dicaire	Marie-Josee Dicaire has nothing to disclose.
Claire-Sophie Davoine, Engineer	Mrs. DAVOINE has nothing to disclose.
David Genís Batlle, MD	Dr. GENÍS BATLLE has nothing to disclose.
Guinevere Spurdens	Miss Spurdens has nothing to disclose.
Jillian Hammond	Ms. Hammond has nothing to disclose.
Brandon Gerhart	Mr. gerhart has nothing to disclose.
Mathilde Renaud, MD, PhD	Prof. Renaud has nothing to disclose.
Céline BONNET, MD	Prof. BONNET has nothing to disclose.
Jill S. Napierala, PhD	Dr. Napierala has nothing to disclose.
Ira Deveson, PhD	Dr. Deveson has nothing to disclose.
Marek Napierala, PhD	The institution of Dr. Napierala has received research support from NIH and FARA.
Alexis Brice, MD	Dr. Brice has received personal compensation in the range of $100,000-$499,999 for serving as an officer or member of the Board of Directors for ICM.
Laura Molina-Porcel, MD, PhD	Dr. Molina-Porcel has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen.
Danielle D. Seilhean, MD, PhD	Prof. SEILHEAN has nothing to disclose.
Stephan Zuchner, MD, FAAN	Dr. Zuchner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Applied Therapeutics. The institution of Dr. Zuchner has received research support from Muscular Dystrophy Association. The institution of Dr. Zuchner has received research support from CMT Association. Dr. Zuchner has received intellectual property interests from a discovery or technology relating to health care.
Alexandra Durr, MD	The institution of Dr. Durr has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. The institution of Dr. Durr has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology Genetics. The institution of Dr. Durr has received research support from NIH. The institution of Dr. Durr has received research support from BIOGEN. The institution of Dr. Durr has received research support from MINORYX. The institution of Dr. Durr has received research support from TRIPLETS THERAPEUTICS. The institution of Dr. Durr has received research support from Servier. The institution of Dr. Durr has received research support from ANR. The institution of Dr. Durr has received research support from PTC.
Bernard Brais, MD	Dr. Brais has nothing to disclose.
Cheng-Tsung Hsiao, MD, PhD	Dr. Hsiao has nothing to disclose.
Ssu-Ju Fu, PhD	Dr. Fu has nothing to disclose.
Chih-Yung Tang, PhD	Prof. Tang has nothing to disclose.
Chung-Jiuan Jeng, PhD	Prof. Jeng has nothing to disclose.
Oswaldo Lorenzo Betancor, PhD	The institution of Dr. Lorenzo Betancor has received research support from Department of Veterans Affairs. The institution of Dr. Lorenzo Betancor has received research support from Michael J. Fox Foundation.
Anna Park	Miss Park has nothing to disclose.
Caroline Kwon	Ms. Kwon has nothing to disclose.
Sarah Fish	Sarah Fish has nothing to disclose.
Arnav Khera	Mr. Khera has nothing to disclose.
Jeremy R. Weiss	Mr. Weiss has nothing to disclose.
Selina Yu	Selina Yu has nothing to disclose.
Dora Yearout	The institution of Dora Yearout has received research support from Veterans Affairs, NIH, and MJFF reserach grants.
Leo Pallanck	No disclosure on file
Cyrus P. Zabetian, MD	The institution of Dr. Zabetian has received research support from American Parkinson Disease Association. The institution of Dr. Zabetian has received research support from Department of Veterans Affairs. The institution of Dr. Zabetian has received research support from NIH. Dr. Zabetian has a non-compensated relationship as a Member, Scientific Advisory Council with Lewy Body Dementia Association that is relevant to AAN interests or activities.
Ella Chiu	Miss Chiu has nothing to disclose.
Joshua Weiss, PharmD	Mr. Weiss has nothing to disclose.
Lindsey L. Lair, MD, FAAN	Dr. Lair has received personal compensation for serving as an employee of Biohaven. An immediate family member of Dr. Lair has received personal compensation for serving as an employee of PPD/Thermo Fisher Scientific. Dr. Lair has stock in Biohaven. An immediate family member of Dr. Lair has stock in PPD/Thermo Fisher Scientific. Dr. Lair has a non-compensated relationship as a Board Member with NY State Neurological Society that is relevant to AAN interests or activities.

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