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Abstract Details

Factors contributing to the sustainment of exercise in patients with Parkinson’s Disease. The Parkinson’s Foundation Quality Improvement Initiative (PF-QII) dataset
Movement Disorders
S53 - Movement Disorders: Genetics and Clinical Features (4:36 PM-4:47 PM)
007

The PF-QII dataset demonstrated that exercise may slow physical and quality of life declines in Parkinson’s Disease (PD). However, barriers to exercise exist.

Prior cross-sectional studies do not address individual processes that impact changes in exercise participation.

To explore individual processes contributing to changes in exercise.

A mixed methods approach used PF-QII data to categorize 1970 participants with 3 annual visits into “exercise increasers” and “exercise decreasers” using the parametric p-value changes of outcomes based on different absolute cutoffs in random 75% samples.

Groups (exercise maintainers, starters, stoppers, increasers, decreasers and non-exercisers) were compared on mobility, quality of life, hospitalization, and fall variables the following year.

Then, phone interviews were conducted with 40 PF-QII participants from one Center to assess personal factors influencing exercise changes. Qualitative content analysis was completed using iterative open coding combined with deductive codes based on health behavior change models.

A change of 1.5 hours per week was associated with better health with increased exercise or health decrements with decreased exercise. Exercisers were younger, more recently diagnosed, and healthier. The following year, quality of life (PDQ-39) significantly increased (worsened) in the exercise increasers compared to the decreasers (p=0.012), particularly in the emotional well-being and communications subscales. For consistent exercisers, additional hours of exercise increased the odds of decreasing exercise the following year by a factor of 3.6 (CI95% 2.0-6.9). Qualitatively, exercise decreases were frequently due to injuries, depression, or changes in motivation. People with PD rely on their family, friends, and health professionals to trigger and support increasing exercise.

Exercisers fluctuated over time, with exercisers having a greater risk of future exercise decreases. Surprisingly, exercise increasers had lower quality of life the following year. Further studies are needed to elucidate possible perception bias after increasing exercise and changes in perceived expectations or psychosocial burden.

Authors/Disclosures
Miriam R. Rafferty, PhD, PT (Shirley Ryan AbilityLab, Northwestern University)
PRESENTER
No disclosure on file
Margaret Yu, MD (Northwestern University, McGaw Medical Center) No disclosure on file
Danielle Larson, MD (Northwestern University, Feinberg School of Medicine) Dr. Larson has received personal compensation in the range of $0-$499 for serving as a Consultant for Acadia Pharmaceuticals.
No disclosure on file
Tanya Simuni, MD, FAAN (Northwestern University Feinberg School of Medicien) Dr. Simuni has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for cadia, AcureX, Adamas, AskBio, Amneal, Blue Rock Therapeutics, Caraway Therapeutics, Critical Path for Parkinson's Consortium (CPP), Denali, Michael J Fox Foundation, Neuroderm, Sanofi, Sinopia, Roche, Takeda and Vanqua Bio. Dr. Simuni has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for of Koneksa, Neuroderm, Sanofi, UCB, AcureX, Adamas, AskBio, Biohaven, Denali, GAIN, Neuron23 and Roche. Dr. Simuni has received research support from Amneal, Biogen, Neuroderm, Prevail, Roche, and UCB and an investigator for NINDS, MJFF, Parkinson's Foundation.
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file