2019 Annual Meeting | S53 - Movement Disorders: Genetics and Clinical Features

Date Thursday 05/09/19

Time 03:30 PM - 05:30 PM EDT Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program is not expected to be available in the meeting's On Demand product.

Event Type Scientific Platform Session

Moderator(s) Susan B. Bressman, MD, FAAN, Marta San Luciano, MD, FAAN

Topic(s) Movement Disorders

CME Available 2.00 CME credits

Program Materials Program Evaluations

Event Timeline
03:30 PM - 03:41 PM EDT	Abstract	001 - Genome-wide Association Studies of Tourette Syndrome (TS) Confirm a Shared Spectrum of Polygenic Risk across TS and Other Tic Disorders Jeremiah M. Scharf, MD, PhD
03:41 PM - 03:52 PM EDT	Abstract	002 - RDP is associated with bulbar and limb weakness: broadening the phenotype of ATP1A3+ Rapid-Onset Dystonia-Parkinsonism (RDP). Ihtsham Haq, MD, FAAN
03:52 PM - 04:03 PM EDT	Abstract	003 - Association between glucocerebrosidase mutations and Parkinson’s disease in Ireland Diana Angelika Olszewska, MD, PhD
04:03 PM - 04:14 PM EDT	Abstract	004 - Glucocerebrosidase Deficiency Mediates Propagation of Protein Aggregation in a Drosophila Model of Neurodegeneration via Modification of Extracellular Vesicles
04:14 PM - 04:25 PM EDT	Abstract	005 - Genome-Wide Association Study Meta-Analysis For Parkinson Disease Motor Subtypes Isabel Alfradique-Dunham, MD
04:25 PM - 04:36 PM EDT	Abstract	006 - Functional MAOB Gene Intron 13 Polymorphism Predicts Levodopa-induced Dyskinesia in Parkinson’s Disease Alexander Storch, MD
04:36 PM - 04:47 PM EDT	Abstract	007 - Factors contributing to the sustainment of exercise in patients with Parkinson’s Disease. The Parkinson’s Foundation Quality Improvement Initiative (PF-QII) dataset Miriam R. Rafferty, PhD, PT
04:47 PM - 04:58 PM EDT	Abstract	008 - Impaired Action Control in Patients with Functional Movement Disorders Diksha Mohanty, MD
04:58 PM - 05:09 PM EDT	Abstract	009 - Phenotype and Neuropathology of FMR1 Gray Zone Carriers in Community-Dwelling Older Subjects Deborah Hall, MD, PhD, FAAN
05:10 PM - 05:30 PM EDT	Q&A	Q&A Panel with Authors

Faculty Disclosures
Susan B. Bressman, MD, FAAN	The institution of Dr. Bressman has received research support from Michael J Fox Foundation . The institution of Dr. Bressman has received research support from NIH .
Marta San Luciano, MD, FAAN	Dr. San Luciano has received research support from NIH (NINDS).
	No disclosure on file
Christopher T. Whitlow, MD	Dr. Whitlow has nothing to disclose.
Carol Mathews	The institution of Carol Mathews has received research support from NIH. Carol Mathews has received publishing royalties from a publication relating to health care.
Lisa M. Shulman, MD, FAAN	The institution of Dr. Shulman has received research support from NIH. Dr. Shulman has received publishing royalties from a publication relating to health care. Dr. Shulman has received publishing royalties from a publication relating to health care.
Tanya Simuni, MD, FAAN	Dr. Simuni has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for cadia, AcureX, Adamas, AskBio, Amneal, Blue Rock Therapeutics, Caraway Therapeutics, Critical Path for Parkinson's Consortium (CPP), Denali, Michael J Fox Foundation, Neuroderm, Sanofi, Sinopia, Roche, Takeda and Vanqua Bio. Dr. Simuni has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for of Koneksa, Neuroderm, Sanofi, UCB, AcureX, Adamas, AskBio, Biohaven, Denali, GAIN, Neuron23 and Roche. Dr. Simuni has received research support from Amneal, Biogen, Neuroderm, Prevail, Roche, and UCB and an investigator for NINDS, MJFF, Parkinson's Foundation.
J.J. Van Hilten	No disclosure on file
Allison Brashear, MD, MBA, FAAN	Dr. Brashear has received personal compensation for serving as an employee of McKnight Brain Res Found. Dr. Brashear has received personal compensation for serving as an employee of American Board of Psychiatry and Neurology. Dr. Brashear has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for ABPN. Dr. Brashear has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for McKnight Brain Research Foundation i. Dr. Brashear has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Care Directions- start up . Dr. Brashear has stock in Caredirections . The institution of Dr. Brashear has received research support from NINDS. Dr. Brashear has received publishing royalties from a publication relating to health care. Dr. Brashear has received personal compensation in the range of $500-$4,999 for serving as a Special government employee and study section reviewer with NIH. Dr. Brashear has received personal compensation in the range of $0-$499 for serving as a Adminstrative board -travel reimbursement with AAMC.
Brian Magennis	No disclosure on file
Joseph Jankovic, MD, FAAN	Dr. Jankovic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Revance. Dr. Jankovic has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Revance, Allergan. The institution of Dr. Jankovic has received research support from Baylor College of Medicine. Dr. Jankovic has received research support from Abbvie. The institution of Dr. Jankovic has received research support from Abbvie.
Alexander Storch, MD	No disclosure on file
Nelleke C. Van Wouwe, PhD	No disclosure on file
Kathrin LaFaver, MD, FAAN	Dr. LaFaver has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Teva. Dr. LaFaver has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acorda. Dr. LaFaver has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for WALL, WALL & FRAUENHOFER, LLP. The institution of Dr. LaFaver has received research support from Ayers Foundation. Dr. LaFaver has received publishing royalties from a publication relating to health care. Dr. LaFaver has a non-compensated relationship as a Board Member with FND Society that is relevant to AAN interests or activities. Dr. LaFaver has a non-compensated relationship as a Medical Advisor with FND Hope that is relevant to AAN interests or activities.
Jean Christophe Corvol, MD	No disclosure on file
Matthias Lohle	No disclosure on file
Alexandra E. Jacob, MS	No disclosure on file
Deborah Hall, MD, PhD, FAAN	Dr. Hall has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for ��ɫ��. Dr. Hall has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier - Parkinsonism and Related Disorders. Dr. Hall has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Annals of Neurology. The institution of Dr. Hall has received research support from Parkinson's Foundation. The institution of Dr. Hall has received research support from CHDI. The institution of Dr. Hall has received research support from Uniqure. The institution of Dr. Hall has received research support from NIH.
Aisha M. Ali, MD	Dr. Ali has nothing to disclose.
David A. Bennett, MD	Dr. Bennett has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Origent. Dr. Bennett has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving as a Study section, DMC, NACA Council with NIH. Dr. Bennett has received personal compensation in the range of $10,000-$49,999 for serving as a invited lectures with AMCs. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving as a invited paper with National Academy of Sciences. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving as a lecture with National Academy of Neuropsychology.
Aron S. Buchman, MD	No disclosure on file
Kathleen J. Sweadner, PhD	The institution of Dr. Sweadner has received research support from Hope for Annabel, AHC Foundation, and CureAHC. The institution of Dr. Sweadner has received research support from the Chan-Zuckerberg Initiative.
Timothy Lynch, MD	Dr. Lynch has nothing to disclose.
Laurie J. Ozelius, PhD	The institution of Dr. Ozelius has received research support from NIH. Dr. Ozelius has received intellectual property interests from a discovery or technology relating to health care.
Leo Pallanck	No disclosure on file
Owen A. Ross, PhD	Dr. Ross has nothing to disclose.
Orla Hardiman, MD, FRCPI, FAAN	Dr. Hardiman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Wave Pharmaceuticals. Dr. Hardiman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cytokinetics . Dr. Hardiman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Hardiman has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Taylor and Francis. The institution of Dr. Hardiman has received research support from Science Foundation Ireland. The institution of Dr. Hardiman has received research support from HRB.
Jared Cook	No disclosure on file
Diana Angelika Olszewska, MD, PhD	Dr. Olszewska has nothing to disclose.
Ihtsham Haq, MD, FAAN	The institution of Dr. Haq has received research support from NINDS. The institution of Dr. Haq has received research support from the Parkinson's Foundation. The institution of Dr. Haq has received research support from NIMH.
Isabel Alfradique-Dunham, MD	No disclosure on file
Margaret Yu, MD	No disclosure on file
Beverly Snively	The institution of Beverly Snively has received research support from National Institutes of Health. The institution of Beverly Snively has received research support from Duke Endowment. The institution of Beverly Snively has received research support from Department of Defense. The institution of Beverly Snively has received research support from PCORI.
Huw R. Morris, MD, PhD	Dr. Morris has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Morris has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aprinoia. Dr. Morris has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Morris has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for Personal injury / Negligence cases. The institution of Dr. Morris has received research support from Parkinson's UK. The institution of Dr. Morris has received research support from Michael J Fox Foundartion. The institution of Dr. Morris has received research support from Cure Parkinson's Trust. The institution of Dr. Morris has received research support from PSP Association. The institution of Dr. Morris has received research support from CBD Solutions. The institution of Dr. Morris has received research support from Drake Foundation. The institution of Dr. Morris has received research support from Medical Research Council. Dr. Morris has received intellectual property interests from a discovery or technology relating to health care. Dr. Morris has a non-compensated relationship as a Scientific Advisory Board with Cure PSP that is relevant to AAN interests or activities. Dr. Morris has a non-compensated relationship as a Scientific Advisory Board with Parkinson's UK that is relevant to AAN interests or activities.
Andrew Singleton	An immediate family member of Andrew Singleton has received personal compensation for serving as an employee of GeneDx. Andrew Singleton has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Nature Partner Journals Parkinson Disease. Andrew Singleton has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Movement Disorders Journal. An immediate family member of Andrew Singleton has stock in GeneDx. The institution of Andrew Singleton has received research support from Michael J Fox Foundation. Andrew Singleton has received intellectual property interests from a discovery or technology relating to health care. Andrew Singleton has received intellectual property interests from a discovery or technology relating to health care.
Selina Yu	Selina Yu has nothing to disclose.
Marie Y. Davis, MD, PhD	Dr. Davis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. The institution of Dr. Davis has received research support from NIH NINDS. The institution of Dr. Davis has received research support from University of Washington Institute for Stem Cell and Regenerative Medicine. The institution of Dr. Davis has received research support from VA BLRD. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving as a study section grant reviewer with NIH. Dr. Davis has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with Parkinson's Foundation.
Emily J. Hill, MD	Dr. Hill has nothing to disclose.
Miriam R. Rafferty, PhD, PT	No disclosure on file
Diksha Mohanty, MD	Dr. Mohanty has nothing to disclose.
Heinz Reichmann, MD, FAAN	Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bial. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Zambon. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Kyowa. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bial. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Zambon. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Kyowa. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bial. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Zambon. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Thieme. Dr. Reichmann has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wissenschaftsverlag.
Danielle Larson, MD	Dr. Larson has received personal compensation in the range of $0-$499 for serving as a Consultant for Acadia Pharmaceuticals.
Joshua M. Shulman, MD, PhD, FAAN	Dr. Shulman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Helis Medical Foudation. The institution of Dr. Shulman has received research support from National Institutes of Health.
Zhandong Liu	Zhandong Liu has nothing to disclose.
Elizabeth M. Berry-Kravis, MD, PhD	The institution of Dr. Berry-Kravis has received research support from NIH. The institution of Dr. Berry-Kravis has received research support from Ionis. The institution of Dr. Berry-Kravis has received research support from Zynerba. The institution of Dr. Berry-Kravis has received research support from Roche. The institution of Dr. Berry-Kravis has received research support from CDC. The institution of Dr. Berry-Kravis has received research support from FRAXA Research Foundation. The institution of Dr. Berry-Kravis has received research support from GeneTx. The institution of Dr. Berry-Kravis has received research support from Angelman Syndrome Foundation. The institution of Dr. Berry-Kravis has received research support from Acadia. The institution of Dr. Berry-Kravis has received research support from Ultragenyx. The institution of Dr. Berry-Kravis has received research support from Mallinckrodt. The institution of Dr. Berry-Kravis has received research support from Together Strong Foundation. The institution of Dr. Berry-Kravis has received research support from Zevra. The institution of Dr. Berry-Kravis has received research support from Taysha. The institution of Dr. Berry-Kravis has received research support from Tetra. The institution of Dr. Berry-Kravis has received research support from Neuren.
Allan McCarthy, MD	No disclosure on file
Bichum Ouyang	Bichum Ouyang has nothing to disclose.
Giovanni Coppola, MD	Dr. Coppola has received personal compensation for serving as an employee of Regeneron. Dr. Coppola has received stock or an ownership interest from Regeneron.
Lan Luo, MD, MS	Dr. Luo has received personal compensation in the range of $0-$499 for serving as a Consultant for Destum Partners. Dr. Luo has received personal compensation in the range of $0-$499 for serving as a Consultant for Guidepoint Global. Dr. Luo has received research support from BIDMC/HMS.
Jeremiah M. Scharf, MD, PhD	The institution of Dr. Scharf has received research support from the TLC Foundation for Body-Focused Repetitive Behaviors. Dr. Scharf has received personal compensation in the range of $500-$4,999 for serving as a Speaker for a TAA/CDC Family Day Symposium with the Tourette Association of America. Dr. Scharf has a non-compensated relationship as a Scientific Advisory Board Member with the Tourette Association of America that is relevant to AAN interests or activities.

��ɫ����

��ɫ����

��ɫ��

��ɫ��