好色先生

好色先生

Explore the latest content from across our publications

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Impaired Action Control in Patients with Functional Movement Disorders
Movement Disorders
S53 - Movement Disorders: Genetics and Clinical Features (4:47 PM-4:58 PM)
008

Despite being a major cause of neurological disability, FMD remain poorly understood in their underlying neural mechanisms. Recent studies have suggested that patients with FMD experience impaired control over voluntary movements. 

In the current study, we investigated whether action control is impaired in functional movement disorders (FMD) compared to a healthy volunteer (HV) group, using a Compatibility, Stop and Simon conflict task. Understanding action control in FMD may be helpful in developing more specific diagnostic criteria and better evaluation techniques.

Twenty-three patients with a clinically definite diagnosis of FMD were recruited from the University of Louisville Movement Disorders clinic. Twenty-three age-matched HV were enrolled as controls. Subjects completed questionnaires about demographics, clinical presentation and neuropsychological measures. Motor symptom severity was rated with the simplified functional movement disorder rating scale (S-FMDRS). Cognitive testing was done with three action control tasks (Compatibility, Stop, and Simon Arrows task) that tested action initiation, action cancellation and interference control over actions, using a computer and handheld response grips. 

Patients had an average age of 47.2 ± 13.1 years, and 82.6% were female. Average symptom duration was 6.3 ± 7.9 years, and motor symptoms scored 18.5 ± 9.9 on the S-FMDRS. FMD patients were less proficient compared to HV subjects (p=.05) at suppressing incorrect responses. Susceptibility to making fast errors on Simon conflict trials was similar for HV and FMD. Stop signal reaction times were also comparable between groups. No correlation with neuropsychological measurements (anxiety, depression), S-FMDRS scores and action control measurements was observed.

These results suggest that reactive inhibitory control processes, engaged to suppress interference from the spontaneously activated response impulses in the Simon task, are impaired in FMD patients. FMD does not seem to affect the susceptibility to act on impulses or affect global action cancellation as measured by the Stop task. 

Authors/Disclosures
Diksha Mohanty, MD (University of Louisville)
PRESENTER
Dr. Mohanty has nothing to disclose.
Nelleke C. Van Wouwe, PhD (University of Louisville School of Medicine) No disclosure on file
No disclosure on file
Alexandra E. Jacob, MS (University of Alabama Birmingham) No disclosure on file
Kathrin LaFaver, MD, FAAN Dr. LaFaver has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Teva. Dr. LaFaver has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acorda. Dr. LaFaver has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for WALL, WALL & FRAUENHOFER, LLP. The institution of Dr. LaFaver has received research support from Ayers Foundation. Dr. LaFaver has received publishing royalties from a publication relating to health care. Dr. LaFaver has a non-compensated relationship as a Board Member with FND Society that is relevant to AAN interests or activities. Dr. LaFaver has a non-compensated relationship as a Medical Advisor with FND Hope that is relevant to AAN interests or activities.